1.14.18.5: sphingolipid C4-monooxygenase
This is an abbreviated version!
For detailed information about sphingolipid C4-monooxygenase, go to the full flat file.
Word Map on EC 1.14.18.5
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1.14.18.5
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sphingolipids
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sphingoid
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phytosphingosine
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phytoceramide
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oxygen-dependent
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inositolphosphorylceramide
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c4-hydroxylation
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nidulans
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dihydrosphingosine
- 1.14.18.5
- sphingolipids
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sphingoid
- phytosphingosine
- phytoceramide
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oxygen-dependent
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inositolphosphorylceramide
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c4-hydroxylation
- nidulans
- dihydrosphingosine
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 +
Synonyms
bifunctional sphingolipid D4-desaturase/C4-hydroxylase, DES2, DHS hydroxylase, dihydroceramide hydrolase, dihydroceramide hydroxylase, EC 1.14.13.169, LmjF_26_1670, SBH1, SBH2, SC4H, sphinganine C4-hydroxylase, sphinganine C4-monooxygenase, sphingolipid C4-hydroxylase, sphingolipid delta(4)-desaturase/C4-monooxygenase, sphingolipid hydroxylase, SUR2, Sur2p, SYR2, Syr2p
ECTree
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General Information
General Information on EC 1.14.18.5 - sphingolipid C4-monooxygenase
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malfunction
physiological function
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deleting the SUR2 gene reduces hydroxylation of ceramides and suppresses Ca2+ sensitivity of csg2 mutants
malfunction
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yeast strains deficient in Syr2 lack the sphingoid long chain base phytosphingosine
malfunction
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yeast strains deficient in Syr2 lack the sphingoid long chain base phytosphingosine
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sphingolipid C4 hydroxylation by the enzyme influences properties of detergent-insoluble glycolipid-enriched membranes
physiological function
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Sur2p is required for the hydroxylation of C-4 of the sphingoid moiety of ceramide. The enzyme is not essential for growth
physiological function
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SYR2 is necessary for growth inhibition by the cyclic lipodepsipeptide syringomycin E. The SYR2 gene is required for the 4-hydroxylation reaction of sphingolipid long chain bases and is not essential for growth. SYR2 does not play a role in sterol biosynthesis
physiological function
the enzyme plays an essential role in phytosphingolipid synthesis in human skin and other phytosphingolipid-containing tissues
physiological function
C-4 hydroxylation of sphingolipids is important for the antifungal action of syringomycin E. Mutants with defects in C-4 hydroxylated sphingoid base biosynthesis are resistant to this antifungal agent
physiological function
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SYR2 is necessary for growth inhibition by the cyclic lipodepsipeptide syringomycin E. The SYR2 gene is required for the 4-hydroxylation reaction of sphingolipid long chain bases and is not essential for growth. SYR2 does not play a role in sterol biosynthesis
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