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1.14.18.4: phosphatidylcholine 12-monooxygenase

This is an abbreviated version!
For detailed information about phosphatidylcholine 12-monooxygenase, go to the full flat file.

Word Map on EC 1.14.18.4

Reaction

a 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a 1-acyl-2-[(12R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine
+ 2 ferricytochrome b5 +
H2O

Synonyms

castor DELTA12-hydroxylase, CFAH12, CFAH12 protein, CpFAH, CpFAH12, DELTA12 oleate hydroxylase, EC 1.14.13.26, FAH, FAH12, LFAH12, oleate 12-hydroxylase, oleate DELTA12-hydroxylase, oleate hydroxylase, oleoyl-12-hydroxylase, oxygenase, oleate DELTA12-mono, ricinoleic acid synthase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.4 phosphatidylcholine 12-monooxygenase

Engineering

Engineering on EC 1.14.18.4 - phosphatidylcholine 12-monooxygenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
M295L
site-directed mutagenesis, expression of the mutant FAH12gene in yeast does not result in any obvious changes in the ratio of hydroxy and diunsaturated fatty acids accumulating
F49S/V242A/H319Q
additional information