1.14.18.2: CMP-N-acetylneuraminate monooxygenase

This is an abbreviated version!
For detailed information about CMP-N-acetylneuraminate monooxygenase, go to the full flat file.

Word Map on EC 1.14.18.2

Reaction

CMP-N-acetylneuraminate
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
CMP-N-glycoloylneuraminate
+ 2 ferricytochrome b5 +
H2O

Synonyms

CMAH, CMP Neu5Ac hydroxylase, CMP-N-acetylneuraminate hydroxylase, CMP-N-acetylneuraminate,NAD(P)H:oxygen oxidoreductase (hydroxylating), CMP-N-acetylneuraminic acid hydroxylase, CMP-Neu5Ac hydroxylase, CMP-NeuAc hydroxylase, cytidine monophosphate-N-acetylneuraminic acid hydroxylase, cytidine monophospho-N-acetylneuraminic acid hydroxylase, EC 1.14.13.45, oxygenase, cytidine monophosphoacetylneuraminate mono-, pcmah

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.2 CMP-N-acetylneuraminate monooxygenase

Inhibitors

Inhibitors on EC 1.14.18.2 - CMP-N-acetylneuraminate monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
2,2'-dipyridyl
3'-AMP
-
5 mM, complete inhibition
3'-CMP
-
5 mM, about 20% inhibition
3'-UMP
-
5 mM, about 90% inhibition
5'-AMP
-
5 mM, about 78% inhibition
5'-UMP
-
5 mM, about 15% inhibition
anti-(rat cytochrome b5) antiserum
-
Ca2+
-
0.5 mM, 12% inhibition
cardiolipin
-
3 mM, 15% inhibition
CHAPS
-
15 mM, complete inhibition
cholic acid
-
10 mM, 89% inhibition
CMP-N-glycoloylneuraminate
-
-
Co2+
-
-
Cu2+
-
-
decylglucopyranoside
-
5 mM, 22% inhibition
ferrozine
Hg2+
-
slight inhibition
Mg2+
-
-
Na2HPO4
-
2 mM, 86% inhibition
Na4P2O7
-
2 mM, 54% loss of activity
NaCl
-
above 100 mM
Ni2+
-
-
octylglucopyranoside
-
30 mM, 48% inhibition
phosphatidic acid
-
3 mM, 20% inhibition
phosphatidylinositol
-
3 mM, 68% inhibition
Tiron
Zn2+
-
-
Zwittergent 3-12
-
5 mM, 40% inhibition
additional information
-
not inhibited by increased ionic strength, no inhibition by 1 M NaCl
-