1.14.18.2: CMP-N-acetylneuraminate monooxygenase

This is an abbreviated version!
For detailed information about CMP-N-acetylneuraminate monooxygenase, go to the full flat file.

Word Map on EC 1.14.18.2

Reaction

CMP-N-acetylneuraminate
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
CMP-N-glycoloylneuraminate
+ 2 ferricytochrome b5 +
H2O

Synonyms

CMAH, CMP Neu5Ac hydroxylase, CMP-N-acetylneuraminate hydroxylase, CMP-N-acetylneuraminate,NAD(P)H:oxygen oxidoreductase (hydroxylating), CMP-N-acetylneuraminic acid hydroxylase, CMP-Neu5Ac hydroxylase, CMP-NeuAc hydroxylase, cytidine monophosphate-N-acetylneuraminic acid hydroxylase, cytidine monophospho-N-acetylneuraminic acid hydroxylase, EC 1.14.13.45, oxygenase, cytidine monophosphoacetylneuraminate mono-, pcmah

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.2 CMP-N-acetylneuraminate monooxygenase

General Stability

General Stability on EC 1.14.18.2 - CMP-N-acetylneuraminate monooxygenase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
10 mM in the initial homogenization buffer is required for stability during 60-90 min incubation
after each cycle of freezing and thawing, 25% loss of activity
-
enzyme is greatly stabilized by CMP-N-acetylneuraminate
-