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1.14.18.1: tyrosinase

This is an abbreviated version!
For detailed information about tyrosinase, go to the full flat file.

Word Map on EC 1.14.18.1

Reaction

2 L-dopa +

O2
= 2 dopaquinone + 2 H2O

Synonyms

AbPPO1, AbPPO4, AbTYR, aurone synthase, catalase-phenol oxidase, catechol oxidase, catecholase, CATPO, chlorogenic acid oxidase, chlorogenic oxidase, cresolase, cresolase/monophenolase, CsPPO, CZA14Tyr, deoxy-tyrosinase, dihydroxy-L-phenylalanine:oxygen oxidoreductase, Diphenol oxidase, diphenolase, dopa oxidase, EC 1.10.3.1, EC 1.14.17.2, Hc-derived phenoloxidase, Hc-phenoloxidase, HcPO, HdPO, hemocyanin-derived phenoloxidase, jrPPO1, jrTYR, L-DOPA monophenolase, L-DOPA oxidase, L-DOPA:oxygen oxidoreductase, L-tyrosine hydroxylase, MdPPO1, melC2, MelC2 tyrosinase, met-tyrosinase, monophenol dihydroxyphenylalanine:oxygen oxidoreductase, monophenol monooxidase, monophenol monooxygenase, monophenol monoxygenase, monophenol oxidase, monophenol oxygen oxidoreductase, monophenol, 3,4-dihydroxy L-phenylalanine (L-DOPA):oxygen oxidoreductase, monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase, monophenol, dihydroxy-L-phenylalanine:oxygen oxidoreductase, monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, monophenol, L-Dopa: oxidoreductase, monophenol, L-DOPA: oxygen oxidoreductase, monophenol, o-diphenol: oxygen oxidoreductase, monophenol, o-diphenol:O2 oxidoreductase, monophenol, o-diphenol:oxygen oxido-reductase, monophenol, o-diphenol:oxygen oxidoreductase, monophenol, polyphenol oxidase, monophenol: dioxygen oxidoreductases, hydroxylating, monophenolase, monphenol mono-oxygenase, More, mTyr, murine tyrosinase, mushroom tyrosinase, mushroom tyrosine, N-acetyl-6-hydroxytryptophan oxidase, o-diphenol oxidase, o-diphenol oxidoreductase, o-diphenol oxygen oxidoreductase, o-diphenol: O2 oxidoreductase, o-diphenol: oxidoreductase, o-diphenol:O2 oxidoreductase, o-diphenol:oxygen oxidoreductase, o-diphenolase, OCA1, Orf13, oxygen oxidoreductase, phenol oxidase, phenol oxidases, phenolase, phenoloxidase, PO, polyaromatic oxidase, polyphenol oxidase, polyphenol oxidase 3, polyphenol oxidase 4, polyphenol oxidase B, polyphenolase, polyphenoloxidase, PotPPO, PPO, PPO 3, PPO B, PPO1, PPO2, PPO3, pro-PO III, prophenoloxidase III, pyrocatechol oxidase, SPRTyr, ST94, ST94t, tryosinase, tryrosinase, TY, tyr, TYR1, TYR2, tyrA, TyrBm, tyrosinase, tyrosinase 2, tyrosinase 4, tyrosinase diphenolase, tyrosine-dopa oxidase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.1 tyrosinase

pH Range

pH Range on EC 1.14.18.1 - tyrosinase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3 - 5.5
-
-
3 - 7
-
activity range, drastic decrease in activity at pH 7.5 and above
3 - 8
PPO activity increases with pH from pH 3.0 to pH 7.0 and decreases slightly as pH increases from pH 7.0 to pH 8.0, but this general pattern is affected by the substrate, pH optima for PPO activity depend on the phenolic substrates, detailed overview
3 - 9
3.4 - 6.3
-
over 50% of maximal activity within this range
3.5 - 6
3.5 - 7.5
3.5 - 8
-
measuring effect of pH on PPO activity and stability
3.7 - 7.7
-
pH 3.7: 50% of maximal activity, pH 7.7: 50% of maximal activity
4 - 10
4 - 7
-
for diphenolase activity of tyrosinase
4 - 8
4 - 9
4.1 - 4.4
-
74% and 87% of maximal activity
4.3 - 5
-
pH 4.3: 62% of maximal activity, pH 5.3: 79% of maximal activity
4.5 - 10
activity range, profile overview
4.5 - 7
-
assay at pH 4.5.and 7.0
4.5 - 7.5
4.5 - 8
-
pH 4.5: about 70% of maximal activity, pH 8.0: about 50% of maximal activity, negligible activity below pH 4 and above pH 9, isoenzyme PPO I
4.5 - 9
-
the activity of mushrom tyrosinase is studied in this pH range
5 - 10
the proteolytically activated mushroom tyrosinase shows over 50% of its maximal activity in the range of pH 5-10 and accepts a wide range of substrates including mono- and diphenols, flavonols and chalcones
5 - 6.5
-
studies on effect of pH show retention of more than 90% activity over a pH range 5.0-6.5
5 - 7
5 - 7.5
-
over 50% activity within this range, reduced activity above and below
5 - 8
5 - 9
5.5
-
no activity below
5.5 - 8
5.5 - 8.5
active at this pH-range
5.7
-
the optimum pH for broccoli PPO is 5.7 with catechol and 4-methylcatechol as substrates
5.7 - 7.8
Vibrio tyrosinaticus
-
pH 5.7: 50% of maximal activity, pH 6.6-7.8: optimum
6 - 10
-
active at this pH-range
6 - 7.8
6 - 9
pH 6.0: about 55% of maximal activity, pH 9.0: about 45% of maximal activity
6 - 9.5
-
highest activity and stability within a neutral and alkaline pH range
6.5 - 10
-
pH 6.5: about 60% of maximal activity, pH 10.0: about 10% of maximal activity
6.5 - 8.5
7.5 - 10.5
-
less than 50% activity below pH 7.5 and above pH 10.5, L-dopa oxidation at 50°C
8 - 9.5
-
pH 8.0: about 30% of maximal activity, pH 9.0: maximal activity, pH 9.5: no activity
additional information