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1.14.18.1: tyrosinase

This is an abbreviated version!
For detailed information about tyrosinase, go to the full flat file.

Word Map on EC 1.14.18.1

Reaction

2 L-dopa +

O2
= 2 dopaquinone + 2 H2O

Synonyms

AbPPO1, AbPPO4, AbTYR, aurone synthase, catalase-phenol oxidase, catechol oxidase, catecholase, CATPO, chlorogenic acid oxidase, chlorogenic oxidase, cresolase, cresolase/monophenolase, CsPPO, CZA14Tyr, deoxy-tyrosinase, dihydroxy-L-phenylalanine:oxygen oxidoreductase, Diphenol oxidase, diphenolase, dopa oxidase, EC 1.10.3.1, EC 1.14.17.2, Hc-derived phenoloxidase, Hc-phenoloxidase, HcPO, HdPO, hemocyanin-derived phenoloxidase, jrPPO1, jrTYR, L-DOPA monophenolase, L-DOPA oxidase, L-DOPA:oxygen oxidoreductase, L-tyrosine hydroxylase, MdPPO1, melC2, MelC2 tyrosinase, met-tyrosinase, monophenol dihydroxyphenylalanine:oxygen oxidoreductase, monophenol monooxidase, monophenol monooxygenase, monophenol monoxygenase, monophenol oxidase, monophenol oxygen oxidoreductase, monophenol, 3,4-dihydroxy L-phenylalanine (L-DOPA):oxygen oxidoreductase, monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase, monophenol, dihydroxy-L-phenylalanine:oxygen oxidoreductase, monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, monophenol, L-Dopa: oxidoreductase, monophenol, L-DOPA: oxygen oxidoreductase, monophenol, o-diphenol: oxygen oxidoreductase, monophenol, o-diphenol:O2 oxidoreductase, monophenol, o-diphenol:oxygen oxido-reductase, monophenol, o-diphenol:oxygen oxidoreductase, monophenol, polyphenol oxidase, monophenol: dioxygen oxidoreductases, hydroxylating, monophenolase, monphenol mono-oxygenase, More, mTyr, murine tyrosinase, mushroom tyrosinase, mushroom tyrosine, N-acetyl-6-hydroxytryptophan oxidase, o-diphenol oxidase, o-diphenol oxidoreductase, o-diphenol oxygen oxidoreductase, o-diphenol: O2 oxidoreductase, o-diphenol: oxidoreductase, o-diphenol:O2 oxidoreductase, o-diphenol:oxygen oxidoreductase, o-diphenolase, OCA1, Orf13, oxygen oxidoreductase, phenol oxidase, phenol oxidases, phenolase, phenoloxidase, PO, polyaromatic oxidase, polyphenol oxidase, polyphenol oxidase 3, polyphenol oxidase 4, polyphenol oxidase B, polyphenolase, polyphenoloxidase, PotPPO, PPO, PPO 3, PPO B, PPO1, PPO2, PPO3, pro-PO III, prophenoloxidase III, pyrocatechol oxidase, SPRTyr, ST94, ST94t, tryosinase, tryrosinase, TY, tyr, TYR1, TYR2, tyrA, TyrBm, tyrosinase, tyrosinase 2, tyrosinase 4, tyrosinase diphenolase, tyrosine-dopa oxidase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.1 tyrosinase

pH Optimum

pH Optimum on EC 1.14.18.1 - tyrosinase

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
11
the optimum pH for diphenol oxidase activity of endogenous TyrA is determined to be pH 11.0 and pH 8.0 for recombinant TyrA
3
-
oxidation of 4-methylcatechol
3.5 - 4.5
-
dependent on the substrate, overview
3.5 - 5
-
catecholase activity
4.2
-
optima at pH 4.2 and pH 7.0
4.5 - 5
-
with 4-methylcatechol, chlorogenic acid and (+)-catechin
5 - 6.5
-
catecholase activity entrapped in reverse micelles
5 - 8
-
dopa oxidation
5.2
-
optimum pH of cherry PPO, with D-tyrosine as substrate
5.3
-
PPO activity shows two pH optima, at 5.3 and 7.0 at 25°C when pyrogallol is used as the substrate
5.5 - 6.5
-
catecholase activity
5.5 - 7.3
-
dopa oxidase activity
5.7
-
substrate catechol
6 - 6.5
6 - 7
pH-optimum
6.2
Mushroom
-
free enzyme
6.5 - 7
-
pH-optimum
6.6 - 7.8
Vibrio tyrosinaticus
-
-
6.7 - 7.2
-
-
6.8 - 7.8
-
tyrosine hydroxylase activity
6.9
for PPO2, activation of the PPOs shifts the pH optima to 7
7.9
-
substrate dopa, 2 pH-maxima at pH 6.5 and pH 7.9
8 - 9.5
-
pH-optimum
9 - 9.6
-
isoenzymes 1-3
additional information