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12
(2E)-but-2-enoic acid
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.91
(2E,4E)-hexa-2,4-dienoic acid
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.0317
(Z)-2-(4-hydroxybenzylidene)-4-hydroxybenzofuran-3(2H)-one
-
-
0.0384
(Z)-2-(4-hydroxybenzylidene)-6-hydroxybenzofuran-3(2H)-one
-
-
0.038
(Z)-4,6-dihydroxy-2-(4-hydroxybenzylidene)benzofuran-3(2H)-one
-
-
0.0003
1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane
-
inhibition is competitive and reversible, about 15times more potent than kojic acid
0.0011 - 0.0016
1-pentanoyl-3-(4-methoxyphenyl)thiourea
-
pH 6.8, 25°C
0.015
2,4,6-cycloheptatriene-1-one
Mushroom
-
-
0.35
2,5-dihydroxybenzoic acid
-
-
0.041
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl (2E)-3-(4-chlorophenyl)prop-2-enoate
-
pH 6.8, 25°C
0.013
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl (2E)-3-(4-hydroxyphenyl)prop-2-enoate
-
pH 6.8, 25°C
0.065
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 2,4-dihydroxybenzoate
-
pH 6.8, 25°C
0.009
2-(chloromethyl)-10-(2-fluorophenyl)-7,7-dimethyl-6,7,8,10-tetrahydropyrano[3,2-b]chromene-4,9-dione
-
pH 7.2, temperature not specified in the publication
2.4
2-(hydroxymethyl)-7,7-dimethyl-10-phenyl-6,7,8,10-tetrahydropyrano[3,2-b]chromene-4,9-dione
-
pH 7.2, temperature not specified in the publication
0.007895 - 0.01261
2-acetylamino-1,3,4-thiadiazole-5-sulfonamide
0.0012
2-chlorobenzaldehyde thiosemicarbazone
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
7.5
2-chlorophenol
-
in 100 mM phosphate buffer, pH 6.8, at 25°C
1
2-ethyl-3-hydroxy-4H-pyran-4-one
-
pH 7.2, temperature not specified in the publication
1.75
2-hydroxybenzoic acid
-
-
0.009 - 0.5
2-mercaptoethanol
7.93
2-oxoglutaric acid
-
pH 7.0, 25°C
0.0051
2-[(1E,2E)-N-hydroxy-3-(pyridin-2-yl)prop-2-enimidoyl]phenol
-
pH 6.8, 30°C
0.0025
2-[(1E,2E)-N-hydroxy-3-(pyridin-3-yl)prop-2-enimidoyl]phenol
-
pH 6.8, 30°C
0.52 - 4.3
3,4-dihydroxybenzoic acid
0.064
3-hydroxy-1,2-dimethyl-4(1H)-pyridone
-
pH 7.2, temperature not specified in the publication
2.5
3-hydroxycinnamic acid
-
-
0.006
4-(2-(hydroxymethyl)-7,7-dimethyl-4,9-dioxo-4,6,7,8,9,10-hexahydropyrano[3,2-b]chromen-10-yl)benzonitrile
-
pH 7.2, temperature not specified in the publication
0.15 - 0.243
4-Aminobenzoic acid
0.00125
4-chlorobenzaldehyde thiosemicarbazone
-
in 5 0mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.00047
4-dodecylresorcinol
-
pH 6.8, 37°C
0.06
4-formyl-2-methoxyphenyl (4-phenylpiperazin-1-yl)acetate
-
pH 6.8, 25°C
0.0005
4-hexylresorcinol
-
pH 6.8, 37°C
0.35 - 2
4-hydroxybenzoic acid
0.24
4-hydroxycinnamic acid
-
-
3.7
4-hydroxyphenyl beta-D-xyloside
-
in 100 mM sodium phosphate buffer (pH 6.8), at 25°C
0.2
4-hydroxyphenyl beta-xylodioside
-
in 100 mM sodium phosphate buffer (pH 6.8), at 25°C
0.057
4-hydroxyphenyl beta-xylotetraoside
-
in 100 mM sodium phosphate buffer (pH 6.8), at 25°C
0.29
4-hydroxyphenyl beta-xylotrioside
-
in 100 mM sodium phosphate buffer (pH 6.8), at 25°C
0.23 - 104
4-methylcatechol
0.00029 - 0.00105
4-xylidine-bis(dithiocarbamate) sodium salt
0.00198 - 0.16
5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone
0.013 - 0.057
5-hydroxy-2-(hydroxymethyl)-2H-pyran-4-one
0.145
5-hydroxy-4-oxo-4H-pyran-2-carboxylic acid
-
pH 7.2, temperature not specified in the publication
0.005
5-hydroxyindole
-
dopa oxidase inhibition
0.148
6-hydroxykaempferol
-
a competitive inhibitor of tyrosinase, L-DOPA as a substrate
0.0473 - 0.367
ascorbic acid
0.277 - 0.825
Bathocuproinesulfonate
0.0131 - 0.75
benzoic acid
0.0057 - 0.0141
benzyldithiocarbamate sodium salt
0.031
beta-mercaptoethanol
-
at 25°C
0.008 - 0.013
butylxanthate sodium salt
0.11
cefazolin
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.0129
cefodizime
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.074 - 0.082
Citric acid
0.04 - 0.078
deoxyarbutin
0.00034 - 0.267
diethyldithiocarbamate
0.0014 - 0.0138
ethylxanthate sodium salt
18
gamma-picolyl heptyl amine
-
in 0.1 M phosphate buffer (pH 6.5)
20
gamma-picolyl pentyl amine
-
in 0.1 M phosphate buffer (pH 6.5)
23
gamma-picolyl propyl amine
-
in 0.1 M phosphate buffer (pH 6.5)
0.00179 - 0.16
glutathione
2.51
hexanoic acid
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.005 - 0.025
hexylxanthate sodium salt
1.62
KCl
-
competitive vs. L-dopa
0.001 - 0.0223
kojic acid
0.00039
kuraridinol
-
noncompetitive inhibition
0.000045 - 0.014
kurarinol
0.0168
L-ascorbic acid
-
pH 6.5, 35°C, versus L-tyrosine
0.00137
L-cysteine chloride
-
pH 6.5, 35°C, versus L-tyrosine
4.33 - 28.6
L-phenylalanine
1.75
L-tyrosine
-
at 25°C
1.82
NaCl
-
competitive vs. L-dopa
1.54
octanoic acid
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.0000743
oxalic acid
-
at 25°C
0.267
p-aminobenzenesulfonamide
-
at 25°C
0.052
p-Aminobenzoic acid
-
-
0.17 - 0.25
p-nitrophenol
0.000068 - 0.000892
Phenylthiourea
0.005 - 0.011
propylxanthate sodium salt
0.00196 - 0.00282
Salicylhydroxamic acid
0.67
salicylic acid
-
pH 6.5, 35°C
0.25
Sodium azide
-
pH 6.5, 35°C
0.074
Sodium cyanide
-
pH 6.5, 35°C
0.00000179
Sodium diethyl dithiocarbamate
-
pH 6.5, 35°C, versus L-tyrosine
0.0072 - 0.0218
sodium iso-butylxanthate
0.0061 - 0.0422
sodium iso-pentylxanthate
0.0098 - 0.0129
sodium iso-propylxanthate
0.0164
Sodium metabisulfite
-
pH 6.5, 35°C, versus L-tyrosine
0.0317 - 0.082
Sodium sulfate
0.0074
sophoraflavanone G
-
-
0.0214
syringic acid
-
at 25°C
0.0015
[4-oxo-2-(pyridin-4-ylmethylene-hydrazono)-thiazolidin-5-ylidene]-acetic acid methyl ester
-
pH 6.8, 25°C, substrate L-DOPA
additional information
additional information
-
0.007895
2-acetylamino-1,3,4-thiadiazole-5-sulfonamide
-
pH 6.8, 25°C
0.01261
2-acetylamino-1,3,4-thiadiazole-5-sulfonamide
-
pH 6.8, 25°C
0.009
2-mercaptoethanol
-
pH 6.5, 30°C
0.01
2-mercaptoethanol
-
pH 6.5, 30°C
0.01
2-mercaptoethanol
-
pH 6.5, 30°C
0.01
2-mercaptoethanol
-
pH 6.5, 30°C
0.084
2-mercaptoethanol
-
pH 6.5, 35°C, versus L-tyrosine
0.5
2-mercaptoethanol
-
-
0.52
3,4-dihydroxybenzoic acid
-
vs. O2
4.3
3,4-dihydroxybenzoic acid
-
-
0.15
4-Aminobenzoic acid
-
at an inhibitor concentration of 0.1 mM, with 4-methylcatechol as a substrate, mixed inhibition
0.2
4-Aminobenzoic acid
-
at an inhibitor concentration of 0.133 mM, with 4-methylcatechol as a substrate, mixed inhibition
0.243
4-Aminobenzoic acid
-
at an inhibitor concentration of 0.243 mM, with 4-methylcatechol as a substrate, mixed inhibition
0.35
4-hydroxybenzoic acid
-
vs. O2
0.375
4-hydroxybenzoic acid
-
vs. ascorbic acid
0.5
4-hydroxybenzoic acid
-
vs. p-coumaric acid
0.75
4-hydroxybenzoic acid
-
vs. caffeic acid
2
4-hydroxybenzoic acid
-
-
0.23
4-methylcatechol
Mushroom
-
in bis(2-ethylhexyl)sodium sulfosuccinate-isooctane reverse micelles
3.6
4-methylcatechol
Mushroom
-
in H2O, substrate inhibition
104
4-methylcatechol
-
weak substrate inhibition
0.00029
4-xylidine-bis(dithiocarbamate) sodium salt
-
catecholase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 27°C
0.00064
4-xylidine-bis(dithiocarbamate) sodium salt
-
cresolase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 27°C
0.00095
4-xylidine-bis(dithiocarbamate) sodium salt
-
cresolase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 37°C
0.00105
4-xylidine-bis(dithiocarbamate) sodium salt
-
catecholase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 37°C
0.00198
5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone
-
value for inhibition of diphenolase activity using L-tyrosine as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C
0.16
5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone
-
value for inhibition of monophenolase activity using L-Dopa as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C
0.013
5-hydroxy-2-(hydroxymethyl)-2H-pyran-4-one
-
non-competitive vs. L-dopa
0.057
5-hydroxy-2-(hydroxymethyl)-2H-pyran-4-one
-
non-competitive vs. L-tyrosine
0.0473
ascorbic acid
-
-
0.056
ascorbic acid
-
catechol as a substrate
0.0581
ascorbic acid
-
at an inhibitor concentration of 0.2 mM, with 4-methylcatechol as a substrate, competitive inhibition
0.0667
ascorbic acid
-
at an inhibitor concentration of 0.0126 mM, with pyrogallol as a substrate, mixed inhibition
0.0678
ascorbic acid
-
at an inhibitor concentration of 0.233 mM, with 4-methylcatechol as a substrate, competitive inhibition
0.082
ascorbic acid
-
at an inhibitor concentration of 0.1 mM, with 4-methylcatechol as a substrate, competitive inhibition
0.088
ascorbic acid
-
4-methyl catechol as a substrate
0.1
ascorbic acid
-
at an inhibitor concentration of 0.0082 mM, with pyrogallol as a substrate, mixed inhibition
0.133
ascorbic acid
-
at an inhibitor concentration of 0.057 mM, with pyrogallol as a substrate, mixed inhibition
0.133
ascorbic acid
-
at an inhibitor concentration of 0.133 mM, with catechol as a substrate, mixed inhibition
0.3
ascorbic acid
-
at an inhibitor concentration of 0.1 mM, with catechol as a substrate, mixed inhibition
0.367
ascorbic acid
-
at an inhibitor concentration of 0.0408 mM, with catechol as a substrate, mixed inhibition
0.277
Bathocuproinesulfonate
-
vs. caffeic acid
0.284
Bathocuproinesulfonate
-
vs. O2
0.561
Bathocuproinesulfonate
-
vs. p-coumaric acid
0.825
Bathocuproinesulfonate
-
vs. ascorbic acid
0.0131
benzoic acid
-
pH 6.5, 35°C
0.45
benzoic acid
-
vs. O2
0.53 - 0.6
benzoic acid
-
versus different substrates, pH and temperature not specified in the publication
0.7
benzoic acid
-
vs. p-coumaric acid
0.75
benzoic acid
-
vs. caffeic acid
0.0057
benzyldithiocarbamate sodium salt
-
catecholase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 37°C
0.0059
benzyldithiocarbamate sodium salt
-
cresolase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 37°C
0.0094
benzyldithiocarbamate sodium salt
-
catecholase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 27°C
0.0141
benzyldithiocarbamate sodium salt
-
cresolase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 27°C
0.9
beta-arbutin
inhibition of diphenolase activity, pH and temperature not specified in the publication
1.42
beta-arbutin
inhibition of monophenolase activity, pH and temperature not specified in the publication
0.008
butylxanthate sodium salt
-
for the cresolase activity
0.013
butylxanthate sodium salt
-
for the catecholase activity
0.44 - 0.59
Cinnamic acid
-
versus different substrates, pH and temperature not specified in the publication
1.4
Cinnamic acid
-
noncompetitive vs. pyrogallol
2
Cinnamic acid
-
noncompetitive vs. catechol
0.074
Citric acid
-
4-methyl catechol as a substrate
0.082
Citric acid
-
catechol as a substrate
17
Cl-
-
human tyrosinase source TXM13 pigment cell
38.9
Cl-
-
human tyrosinase source HEK293-TYR
0.08
CN-
-
tyrosine hydroxylase inhibition
0.09
CN-
-
dopa oxidase inhibition
0.095
CN-
Vibrio tyrosinaticus
-
competitive vs. tyrosine
0.0162
CO
-
vs. O2
0.062
CO
-
vs. p-coumaric acid
0.15
CO
-
vs. ascorbic acid
0.338
CO
-
vs. caffeic acid
0.04
deoxyarbutin
inhibition of diphenolase activity, pH and temperature not specified in the publication
0.078
deoxyarbutin
inhibition of monophenolase activity, pH and temperature not specified in the publication
0.00034
diethyldithiocarbamate
-
non-competitive vs. L-dopa
0.0013
diethyldithiocarbamate
-
vs. O2
0.0062
diethyldithiocarbamate
-
non-competitive vs. L-tyrosine
0.0119
diethyldithiocarbamate
-
vs. p-coumaric acid
0.03
diethyldithiocarbamate
-
dopa oxidase inhibition
0.03
diethyldithiocarbamate
-
tyrosine hydroxylase
0.04
diethyldithiocarbamate
-
noncompetitive vs. catechol
0.08
diethyldithiocarbamate
-
noncompetitive vs. pyrogallol
0.267
diethyldithiocarbamate
Vibrio tyrosinaticus
-
noncompetitive vs. tyrosine
0.007
EDTA
-
isoenzyme A3
0.068
EDTA
-
catechol as a substrate
0.075
EDTA
-
isoenzyme B3
0.188
EDTA
-
4-methyl catechol as a substrate
0.298
EDTA
-
isoenzyme A1
0.668
EDTA
-
isoenzyme A2
0.0014
ethylxanthate sodium salt
-
for the catecholase activity
0.0138
ethylxanthate sodium salt
-
for the cresolase activity
0.00179
glutathione
-
at an inhibitor concentration of 0.0233 mM, with catechol as a substrate, mixed inhibition
0.00222
glutathione
-
at an inhibitor concentration of 0.02 mM, with catechol as a substrate, mixed inhibition
0.00444
glutathione
-
at an inhibitor concentration of 0.0133 mM, with catechol as a substrate, mixed inhibition
0.0067
glutathione
-
competitive inhibition, at 25°C
0.0205
glutathione
-
at an inhibitor concentration of 0.267 mM, with 4-methylcatechol as a substrate, competitive inhibition
0.0259
glutathione
-
at an inhibitor concentration of 0.233 mM, with 4-methylcatechol as a substrate, competitive inhibition
0.03
glutathione
-
pH 6.5, 30°C
0.03
glutathione
-
pH 6.5, 30°C
0.03
glutathione
-
pH 6.5, 30°C
0.035
glutathione
-
pH 6.5, 30°C
0.0555
glutathione
-
at an inhibitor concentration of 0.167 mM, with 4-methylcatechol as a substrate, competitive inhibition
0.16
glutathione
-
noncompetitive inhibition, at 25°C
0.005
hexylxanthate sodium salt
-
for the cresolase activity
0.025
hexylxanthate sodium salt
-
for the catecholase activity
0.16
KCN
-
noncompetitive vs. catechol
0.2
KCN
-
noncompetitive vs. pyrogallol
0.001
kojic acid
-
isoenzyme A1
0.001
kojic acid
-
isoenzyme B3
0.003
kojic acid
-
isoenzyme A3
0.003
kojic acid
-
isoenzyme B1
0.005
kojic acid
-
pH 7.2, temperature not specified in the publication
0.006
kojic acid
-
isoenzyme A2
0.008
kojic acid
-
isoenzyme B2
0.0088
kojic acid
-
pH 6.8, 30°C
0.01684
kojic acid
-
pH 6.8, 25°C
0.0223
kojic acid
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.000045
kurarinol
-
-
0.014
kurarinol
-
noncompetitive inhibition
0.022
L-cysteine
-
-
0.145
L-cysteine
-
at 25°C
4.33
L-phenylalanine
-
noncompetitive vs. catechol
28.6
L-phenylalanine
-
uncompetitive vs. pyrogallol
0.172
mimosine
-
with tyramine as substrate
0.536
mimosine
-
with dopamine as substrate
1.25
NaN3
-
noncompetitive vs. catechol
1.8
NaN3
-
noncompetitive vs. pyrogallol
0.97
orcinol
-
competitive vs. pyrogallol
1.43
orcinol
-
mixed inhibition vs. catechol
0.88
p-Cresol
-
competitive vs. catechol
0.9
p-Cresol
-
uncompetitive vs. pyrogallol
0.17
p-nitrophenol
-
competitive vs. catechol
0.25
p-nitrophenol
-
competitive vs. pyrogallol
0.000068
Phenylthiourea
-
with dopamine as substrate
0.000892
Phenylthiourea
-
with tyramine as substrate
0.005
propylxanthate sodium salt
-
for the catecholase activity
0.011
propylxanthate sodium salt
-
for the cresolase activity
4.25
Quinoline
-
competitive vs. catechol
4.7
Quinoline
-
noncompetitive vs. pyrogallol
6.4
resorcinol
-
noncompetitive vs. pyrogallol
7.9
resorcinol
-
competitive vs. catechol
0.00196
Salicylhydroxamic acid
pH 6.0, 30°C
0.00282
Salicylhydroxamic acid
pH 6.0, 30°C
0.0072
sodium iso-butylxanthate
-
inhibition of cresolase activity
0.0218
sodium iso-butylxanthate
-
inhibition of catecholase activity
0.0061
sodium iso-pentylxanthate
-
inhibition of cresolase activity
0.0422
sodium iso-pentylxanthate
-
inhibition of catecholase activity
0.0098
sodium iso-propylxanthate
-
inhibition of cresolase activity
0.0129
sodium iso-propylxanthate
-
inhibition of catecholase activity
0.0317
Sodium sulfate
-
4-methyl catechol as a substrate
0.082
Sodium sulfate
-
catechol as a substrate
0.07
Thiourea
-
mixed inhibition vs. catechol
0.213
Thiourea
-
pH 6.5, 35°C, versus L-tyrosine
0.5
Thiourea
-
noncompetitive vs. pyrogallol
0.0008
tropolone
-
pH 7.2, temperature not specified in the publication
0.00125
tropolone
pH 6.0, 30°C
0.0042
tropolone
-
competitive inhibition
0.00655
tropolone
pH 6.0, 30°C
0.0177
tropolone
-
at an inhibitor concentration of 0.0333 mM, with 4-methylcatechol as a substrate, mixed inhibition
0.0314
tropolone
-
at an inhibitor concentration of 0.133 mM, with 4-methylcatechol as a substrate, mixed inhibition
0.0439
tropolone
-
at an inhibitor concentration of 0.366 mM, with 4-methylcatechol as a substrate, mixed inhibition
0.0477
tropolone
-
at an inhibitor concentration of 0.333 mM, with catechol as a substrate, competitive inhibition
0.0607
tropolone
-
at an inhibitor concentration of 0.667 mM, with catechol as a substrate, competitive inhibition
0.0686
tropolone
-
at an inhibitor concentration of 2.67 mM, with catechol as a substrate, competitive inhibition
0.8
tropolone
-
pH 7.2, temperature not specified in the publication
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
-
inhibition kinetic analysis
-
additional information
additional information
-
Ki value increases with temperature and the results suggest that the enzyme is unstable above 45°C
-
additional information
additional information
-
inhibition kinetic analysis, overview
-
additional information
additional information
-
inhibition kinetic analysis, overview
-
additional information
additional information
inhibition kinetic analysis and mechanism, overview
-
additional information
additional information
-
inhibition kinetics of mono- and diphenolase activities, detailed overview
-
additional information
additional information
-
inhibition kinetics, double-reciprocal kinetic analysis, overview
-
additional information
additional information
-
inhibition kinetics, kinetic analysis of N-acetyl-pentapeptides, overview
-
additional information
additional information
-
inhibition kinetics, type, and constants, and inhibition mechanism of benzylideneacetone, benzylacetone, and 4-phenyl-2-butanol, overview
-
additional information
additional information
-
inhibitory kinetics of 4-hydroxycinnamic acid on mushroom tyrosinase, kinetic modeling
-
additional information
additional information
-
steady-state inhibition kinetics
-