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(([(1E)-phenylmethylidene]amino)oxy)acetic acid + ascorbate + O2
(2R)-hydroxy(([(1E)-phenylmethylidene]amino)oxy)ethanoic acid + ?
non-enzymatic dealkylation yields benzaldoxime and glyoxylate
-
-
?
2,6-difluorohippuric acid + ascorbate + O2
?
-
-
-
?
2-aminohippuric acid + ascorbate + O2
?
-
-
-
?
2-hydroxyhippuric acid + ascorbate + O2
?
-
-
-
?
2-iodohippuric acid + ascorbate + O2
?
-
-
-
?
2-methylhippuric acid + ascorbate + O2
?
-
-
-
?
2-propylmercaptoacetylglycine + ascorbate + O2
?
-
-
-
?
2-pyridylmercaptoacetylglycine + ascorbate + O2
?
-
-
-
?
3-(2-furyl)acryloylglycine + ascorbate + O2
?
-
-
-
?
3-chlorohippuric acid + ascorbate + O2
?
-
-
-
?
3-indolylacetylglycine + ascorbate + O2
?
-
-
-
?
3-methylhippuric acid + ascorbate + O2
?
-
-
-
?
3-phenylthiopropionylglycine + ascorbate + O2
?
-
-
-
?
4-aminohippuric acid + ascorbate + O2
?
-
-
-
?
4-bromohippuric acid + ascorbate + O2
?
-
-
-
?
4-chlorohippuric acid + ascorbate + O2
?
-
-
-
?
4-dimethylaminoazobenzene-4'-sulfonyl-Gly-L-Phe-Gly + ascorbate + O2
4-dimethylaminoazobenzene-4'-sulfonyl-Gly-L-Phe-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
4-ethylhippuric acid + ascorbate + O2
?
-
-
-
?
4-hydroxyhippuric acid + ascorbate + O2
?
-
-
-
?
4-methoxyhippuric acid + ascorbate + O2
?
-
-
-
?
4-methylhippuric acid + ascorbate + O2
?
-
-
-
?
4-nitrobenzoyl-Gly-Gly + ascorbate + O2
?
-
-
-
?
4-nitrohippuric acid + ascorbate + O2
?
-
-
-
?
4-phenylbutyrylglycine + ascorbate + O2
?
-
-
-
?
4-propylhippuric acid + ascorbate + O2
?
-
-
-
?
4-trifluoromethylhippuric acid + ascorbate + O2
?
-
-
-
?
5-phenylpentanoylglycine + ascorbate + O2
?
-
-
-
?
6-phenylhexanoylglycine + ascorbate + O2
?
-
-
-
?
8-phenyloctanoylglycine + ascorbate + O2
?
-
-
-
?
Ac-Tyr-Val-Gly + ascorbate + O2
Ac-Tyr-Val-(2-OH-Gly) + dehydroascorbate + H2O
-
-
-
?
acetyl-D-alanine + ascorbate + O2
?
-
-
-
?
acetyl-Gly-Gly + ascorbate + O2
?
-
-
-
?
acetyl-glycine + ascorbate + O2
?
-
-
-
?
acetyl-L-Tyr-L-Phe-Gly + ascorbate + O2
acetyl-L-Tyr-L-Phe-2-hydroxyglycine + dehydroascorbate + H2O
acetyl-L-Tyr-L-Val-Gly + ascorbate + O2
?
-
-
-
-
?
adrenocorticotrophic hormone(9-14) + ascorbate + O2
adrenocorticotrophic hormone(9-13)-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
Ala-Ile-Gly-Val-Gly-Ala-Pro-Gly + ascorbate + O2
Ala-Ile-Gly-Val-Gly-Ala-Pro-2-hydroxyglycine + dehydroascorbate + H2O
alanyl-L-phenylalanylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
alanyl-L-prolylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
alanylglycyl-L-phenylalanylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
alanylglycyl-L-prolylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
alanylglycylvalyl-L-phenylalanylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
alanylglycylvalyl-L-prolylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
alpha-N-acetyl-adrenocorticotrophic hormone(1-14) + ascorbate + O2
alpha-N-acetyl-adrenocorticotrophic hormone(1-13)-2-hydroxyglycine + dehydroascorbate + H2O
alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2
alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
benzaldehyde imino-oxy acetic acid + O2
benzaldoxime + glyoxylate
assay at 37°C, pH 6.0
-
-
?
benzoyl-D-alanine + ascorbate + O2
?
-
-
-
?
calcitonin + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
?
CBZ-D-alanine + ascorbate + O2
?
-
-
-
?
CBZ-glycine + ascorbate + O2
?
-
-
-
?
chloroacetyl-Gly-Gly + ascorbate + O2
?
-
-
-
?
chromogranin A + ascorbate + O2
? + dehydroascorbate + H2O
cinnamoylglycine + ascorbate + O2
?
-
-
-
?
D-iodo-Tyr-Val-Gly + ascorbate + O2
D-iodo-Tyr-Val-(2-hydroxyglycine) + dehydroascorbate + H2O
labeled substrate
the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide
-
?
D-Tyr-Pro-Gly-Gly + ascorbate + O2
D-Tyr-Pro-Gly-2-hydroxyglycine + dehydroascorbate + H2O
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-NH2 + glyoxylate + dehydroascorbate + H2O
dansyl-D-Tyr-Val-Gly + ascorbate + O2
dansyl-D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
dansyl-D-Tyr-Val-Gly + H2O2
dansyl-D-Tyr-Val-2-hydroxyglycine + H2O
-
peptidylglycine monooxygenase is able to catalyze the hydroxylation of peptidylglycine substrates starting from the oxidized enzyme and using hydrogen peroxide as the only source of oxygen
-
-
?
dansyl-Gly-Gly-Ser-CO-NH-CH2-COOH + ascorbate + O2
?
-
substrate contains either protium or deuterium at the CH2-group
-
-
?
dansyl-L-Tyr-L-Val-Gly + ascorbate + O2
?
dansyl-YVG + ascorbate + O2
?
-
-
-
-
?
dansyl-YVG-COOH + ascorbate + O2
dansyl-YV-NH2 + dehydroascorbate + H2O
diiodotyrosylglycine + ascorbate + O2
diiodotyrosyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
gamma-Glu-Gly-Gly + ascorbate + O2
gamma-Glu-Gly-NH2 + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
glutathione + ascorbate + O2
gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
glyoxylic acid phenylhydrazone + ascorbate + O2
oxalate phenylhydrazide + dehydroascorbate + H2O
-
competitive substrate, inhibitory
-
?
hippuric acid + ascorbate + O2
?
-
-
-
?
hippuric acid + ascorbate + O2
? + dehydroascorbate + H2O
hippuric acid + ascorbate + O2
alpha-hydroxyhippuric acid + dehydroascorbate + H2O
hippuric acid + ascorbate + O2
benzamide + glyoxylate + dehydroascorbate + H2O
-
-
-
?
hippuric acid + ferrocyanide + O2
alpha-hydroxyhippuric acid + ? + H2O
-
-
-
-
?
hippuryl-Gly + ascorbate + O2
?
-
-
-
?
hippuryl-Gly-Gly + ascorbate + O2
?
-
-
-
?
HOOC-NH-CH2-COOH + ascorbate + O2
?
-
substrate contains either protium or deuterium at the CH2-group
-
-
?
hydrocinnamoylglycine + ascorbate + O2
?
-
-
-
?
insulin + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
?
insulin glargine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
?
isocaproylglycine + ascorbate + O2
?
-
-
-
?
L-phenylalanylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
L-prolylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
L-pyroglutamyl-Gly + ascorbate + O2
?
-
-
-
?
leukotriene C4 + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
monoiodo-alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2
monoiodo-alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
monoiodo-D-Tyr-Val-Gly + ascorbate + O2
monoiodo-D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
synthetic peptid
-
?
N-(2,4,6-trinitrophenyl)-D-Tyr-Val-Gly + ascorbate + O2
N-(2,4,6-trinitrophenyl)-D-Tyr-Val-(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
N-(2-furoyl)glycine + ascorbate + O2
?
-
-
-
?
N-(2-thienylcarbonyl)glycine + ascorbate + O2
?
-
-
-
?
N-(4-amino-6-methyl-3-oxoheptanoyl)-L-phenylalanylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
N-(4-amino-6-methyl-3-oxoheptanoyl)glycylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
N-(4-nitrobenzyl)glycine + ascorbate + O2
nitrobenzylamine + glyoxylate + dehydroascorbate + H2O
-
-
-
?
N-(alpha-methylhydrocinnamoyl)glycine + ascorbate + O2
?
-
-
-
?
N-(phenylacetyl)glycine + ascorbate + O2
?
-
-
-
?
N-(phenylacetyl)glycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
N-acetyl-Arg-Gly-Gly + ascorbate + O2
N-acetyl-Arg-Gly-hydroxyglycin + dehydroascorbate + H2O
-
-
-
-
?
N-acetyl-Gln-Lys-Glu-Ser-Thr-Leu-His-Leu-Val-Leu-Arg-Leu-Arg-Gly-Gly + ascorbate + O2
N-acetyl-Leu-Arg-Gly-hydroxyglycin + dehydroascorbate + H2O
-
-
-
-
?
N-acetyl-L-Phe-Gly + ascorbate + O2
N-acetyl-L-Phe-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
?
N-acetyl-L-phenylalanylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
N-acetyl-Leu-Arg-Gly-Gly + ascorbate + O2
N-acetyl-Leu-Arg-Gly-hydroxyglycin + dehydroascorbate + H2O
-
-
-
-
?
N-acetyl-Leu-Arg-Leu-Arg-Gly-Gly + ascorbate + O2
N-acetyl-Leu-Arg-Gly-hydroxyglycin + dehydroascorbate + H2O
-
-
-
-
?
N-acetyl-Leu-His-Leu-Val-Leu-Arg-Leu-Arg-Gly-Gly + ascorbate + O2
N-acetyl-Leu-Arg-Gly-hydroxyglycin + dehydroascorbate + H2O
-
-
-
-
?
N-acetyl-Tyr-Val-Gly + ascorbate + O2
N-acetyl-Tyr-Val-(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
N-acetylglycine + 2 ascorbate + O2
N-acetyl-2-hydroxyglycine + 2 semidehydroascorbate + H2O
-
-
-
-
?
N-acetylglycine + ascorbate + O2
?
-
-
-
?
N-acetylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
N-acetylglycine + ascorbate + O2
acetylamine + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
N-acetylglycine + ascorbate + O2
N-acetyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
N-acetylglycylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
N-benzoylglycine + ascorbate + O2
N-benzoyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
N-butyrylglycine + 2 ascorbate + O2
N-butyryl-2-hydroxyglycine + 2 semidehydroascorbate + H2O
-
-
-
-
?
N-Dan-Tyr-Val-Gly + ascorbate + O2
N-Dan-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
N-DANSYL-D-Tyr-L-Val-Gly + ascorbate + O2
N-DANSYL-D-Tyr-L-Val-(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
N-dansyl-L-Tyr-L-Phe-Gly + ascorbate + O2
N-dansyl-L-Tyr-L-Phe-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
r
N-dansyl-L-Tyr-L-Val-Gly + ascorbate + O2
N-dansyl-L-Tyr-L-Val-2-hydroxyglycine + dehydroascorbate + H2O
N-dansyl-Tyr-Val-D-Ala + ascorbate + O2
?
-
-
-
?
N-dansyl-Tyr-Val-Gly + ascorbate + O2
(S)-N-dansyl-Tyr-Val-alpha-hydroxyglycine + dehydroascorbate + H2O
-
-
-
ir
N-dansyl-Tyr-Val-Gly + ascorbate + O2
N-dansyl-Tyr-Val-(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
N-decanoylglycine + 2 ascorbate + O2
N-decanoyl-2-hydroxyglycine + 2 semidehydroascorbate + H2O
-
-
-
-
?
N-decanoylglycine + ascorbate + O2
?
-
-
-
-
?
N-decanoylglycine + ascorbate + O2
decanoylamine + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
N-hexanoylglycine + 2 ascorbate + O2
N-hexanoyl-2-hydroxyglycine + 2 semidehydroascorbate + H2O
-
-
-
-
?
N-hexanoylglycine + ascorbate + O2
hexanoylamine + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
N-octanoylglycine + 2 ascorbate + O2
N-octanoyl-2-hydroxyglycine + 2 semidehydroascorbate + H2O
-
-
-
-
?
N-propionylglycine + 2 ascorbate + O2
N-propionyl-2-hydroxyglycine + 2 semidehydroascorbate + H2O
-
-
-
-
?
N-trifluoroacetylglycine + ascorbate + O2
N-trifluoroacetyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
N-trinitrophenyl-D-Tyr-Val-Gly + ascorbate + O2
N-trinitrophenyl-D-Tyr-Val-(2-hydroxyglycine) + dehydroascorbate + H2O
N-trinitrophenyl-D-Tyr-Val-Gly + ascorbate + O2
N-trinitrophenyl-D-Tyr-Val-NH2 + glyoxylate + dehydroascorbate + H2O
-
synthetic substrate
-
-
?
N-[(2-phenylcyclopropyl)carbonyl]glycine + ascorbate + O2
N-[(2-phenylcyclopropyl)carbonyl]-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
r
N-[(benzylmercapto)carbonyl]glycine + ascorbate + O2
?
-
-
-
?
N-[(phenylcyclopropyl)carbonyl]glycine + ascorbate + O2
?
-
-
-
?
N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]-L-phenylalanylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
N-[3-(1-leucylpyrrolidin-2-yl)-3-oxopropanoyl]glycylglycine + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
nicotinuric acid + ascorbate + O2
?
-
-
-
?
O-acetyl-L-mandelyl-Gly + ascorbate + O2
O-acetyl-L-mandelyl-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
?
oxytoxin + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
?
peptidyl-glycine + ascorbate + O2
peptidyl-(2-hydroxylglycine) + dehydroascorbate + H2O
peptidylglycine + 2 ascorbate + O2
peptidyl(2-hydroxyglycine) + 2 semidehydroascorbate + H2O
-
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl (S)-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl alpha-hydroxyglycine + semidehydroascorbate + H2O
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxylglycine) + dehydroascorbate + H2O
-
peptidylglycine alpha-hydroxylating monooxygenase reaction
the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide
-
?
Phe-Gly-Phe-Gly + ascorbate + O2
Phe-Gly-Phe-(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
Phe-Gly-Phe-Gly + ascorbate + O2
Phe-Gly-Phe-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
phenylhydantoic acid + ascorbate + O2
?
-
-
-
?
phenylmercaptoacetylglycine + ascorbate + O2
?
-
-
-
?
phenylthioacetylglycine + ascorbate + O2
?
-
-
-
?
proopiomelanocortin peptide + ascorbate + O2
proopiomelanocortin peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
R-CO-NH-CH2-COOH + ascorbate + O2
R-CO-NH2 + CHO-COOH + dehydroascorbate + H2O
S-(1,2-dicarboxyethyl)-glutathione + ascorbate + O2
S-(1,2-dicarboxyethyl)-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
S-(4-nitrobenzyl)-glutathione + ascorbate + O2
S-(4-nitrobenzyl)-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
S-butyl-glutathione + ascorbate + O2
S-butyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
S-decyl-glutathione + ascorbate + O2
S-decyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
S-ethyl-glutathione + ascorbate + O2
S-ethyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
S-hexyl-glutathione + ascorbate + O2
S-hexyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
S-methyl-glutathione + ascorbate + O2
S-methyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
S-octyl-glutathione + ascorbate + O2
S-octyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
S-propyl-glutathione + ascorbate + O2
S-propyl-gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
substance P + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
?
tBOC-Gly + ascorbate + O2
?
-
-
-
?
tBOC-Gly-Gly + ascorbate + O2
?
-
-
-
?
thyrotropin + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
?
trinitrophenyl-D-Tyr-Val-Gly + ascorbate + O2
?
-
activity assay
-
-
?
trinitrophenyl-D-Tyr-Val-Gly + ascorbate + O2
trinitrophenyl-D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
COOH-terminal glycine
-
-
?
ubiquitin + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
-
?
[(4-nitrobenzyl)oxy]acetic acid + ascorbate + O2
nitrobenzyl alcohol + glyoxylate + dehydroascorbate + H2O
-
-
-
?
additional information
?
-
acetyl-L-Tyr-L-Phe-Gly + ascorbate + O2
acetyl-L-Tyr-L-Phe-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
r
acetyl-L-Tyr-L-Phe-Gly + ascorbate + O2
acetyl-L-Tyr-L-Phe-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
r
Ala-Ile-Gly-Val-Gly-Ala-Pro-Gly + ascorbate + O2
Ala-Ile-Gly-Val-Gly-Ala-Pro-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
Ala-Ile-Gly-Val-Gly-Ala-Pro-Gly + ascorbate + O2
Ala-Ile-Gly-Val-Gly-Ala-Pro-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
alpha-N-acetyl-adrenocorticotrophic hormone(1-14) + ascorbate + O2
alpha-N-acetyl-adrenocorticotrophic hormone(1-13)-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
alpha-N-acetyl-adrenocorticotrophic hormone(1-14) + ascorbate + O2
alpha-N-acetyl-adrenocorticotrophic hormone(1-13)-2-hydroxyglycine + dehydroascorbate + H2O
-
inhibitory substrate
-
r
alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2
alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2
alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
?
alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2
alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2
alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2
alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
chromogranin A + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
?
chromogranin A + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
?
chromogranin A + ascorbate + O2
? + dehydroascorbate + H2O
-
-
-
?
D-Tyr-Pro-Gly-Gly + ascorbate + O2
D-Tyr-Pro-Gly-2-hydroxyglycine + dehydroascorbate + H2O
-
synthetic peptide
-
?
D-Tyr-Pro-Gly-Gly + ascorbate + O2
D-Tyr-Pro-Gly-2-hydroxyglycine + dehydroascorbate + H2O
-
optimal activity in sulfonic acid buffers
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
synthetic peptid
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
synthetic peptid
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-NH2 + glyoxylate + dehydroascorbate + H2O
-
-
-
-
?
D-Tyr-Val-Gly + ascorbate + O2
D-Tyr-Val-NH2 + glyoxylate + dehydroascorbate + H2O
-
synthetic substrate
-
-
?
dansyl-D-Tyr-Val-Gly + ascorbate + O2
dansyl-D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
?
dansyl-D-Tyr-Val-Gly + ascorbate + O2
dansyl-D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
?
dansyl-D-Tyr-Val-Gly + ascorbate + O2
dansyl-D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
dansyl-D-Tyr-Val-Gly + ascorbate + O2
dansyl-D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
stereospecific
-
-
?
dansyl-D-Tyr-Val-Gly + ascorbate + O2
dansyl-D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
?
dansyl-L-Tyr-L-Val-Gly + ascorbate + O2
?
-
-
-
-
?
dansyl-L-Tyr-L-Val-Gly + ascorbate + O2
?
-
-
-
-
?
dansyl-YVG-COOH + ascorbate + O2
dansyl-YV-NH2 + dehydroascorbate + H2O
-
-
-
-
?
dansyl-YVG-COOH + ascorbate + O2
dansyl-YV-NH2 + dehydroascorbate + H2O
-
-
-
-
?
hippuric acid + ascorbate + O2
? + dehydroascorbate + H2O
-
C-H bond cleavage is irreversible, protiated and dideuterated substrate
-
-
ir
hippuric acid + ascorbate + O2
? + dehydroascorbate + H2O
-
synthetic substrate
-
-
ir
hippuric acid + ascorbate + O2
alpha-hydroxyhippuric acid + dehydroascorbate + H2O
-
-
-
-
?
hippuric acid + ascorbate + O2
alpha-hydroxyhippuric acid + dehydroascorbate + H2O
-
i.e. N-benzoylglycine
-
?
hippuric acid + ascorbate + O2
alpha-hydroxyhippuric acid + dehydroascorbate + H2O
-
i.e. N-benzoylglycine
-
?
monoiodo-alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2
monoiodo-alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
monoiodo-alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2
monoiodo-alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
monoiodo-alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2
monoiodo-alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
?
N-Dan-Tyr-Val-Gly + ascorbate + O2
N-Dan-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
the product is unstable and dismutates to N-Dan-Tyr-Val-NH2 and glyoxylate (EC4.3.2.5)
-
-
?
N-Dan-Tyr-Val-Gly + ascorbate + O2
N-Dan-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
PAM activity assay, the product is unstable and dismutates to N-Dan-Tyr-Val-NH2 and glyoxylate (EC4.3.2.5)
-
-
?
N-dansyl-L-Tyr-L-Val-Gly + ascorbate + O2
N-dansyl-L-Tyr-L-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
r
N-dansyl-L-Tyr-L-Val-Gly + ascorbate + O2
N-dansyl-L-Tyr-L-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
?
N-dansyl-L-Tyr-L-Val-Gly + ascorbate + O2
N-dansyl-L-Tyr-L-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
-
-
-
r
N-trinitrophenyl-D-Tyr-Val-Gly + ascorbate + O2
N-trinitrophenyl-D-Tyr-Val-(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide
-
?
N-trinitrophenyl-D-Tyr-Val-Gly + ascorbate + O2
N-trinitrophenyl-D-Tyr-Val-(2-hydroxyglycine) + dehydroascorbate + H2O
-
the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide
-
?
peptidyl-glycine + ascorbate + O2
peptidyl-(2-hydroxylglycine) + dehydroascorbate + H2O
-
-
-
-
?
peptidyl-glycine + ascorbate + O2
peptidyl-(2-hydroxylglycine) + dehydroascorbate + H2O
-
PHM catalyzes the stereospecific hydroxylation of the glycine alpha-carbon of all peptidylglycine substrates
-
-
?
peptidylglycine + ascorbate + O2
peptidyl alpha-hydroxyglycine + semidehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl alpha-hydroxyglycine + semidehydroascorbate + H2O
-
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
requirement for O2
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
peptidylglycine alpha-hydroxylating monooxygenase PHM reaction
the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
requirement for O2
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
amidation of neurohormonal peptides
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
peptidylglycine alpha-hydroxylating monooxygenase reaction
the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
most mammalian bioactive peptides possess a C-terminal amino acid amide moiety. Amidated peptides are produced in vivo by the enzymatic cleavage of a precursor with a C-terminal glycine residue. The enzyme catalyzes the key step in the oxidation of the glycine-extended precursors to the alpha-amidated peptide
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
peptidylglycine alpha-hydroxylating monooxygenase reaction
the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
requirement for O2
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
requirement for O2
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
requirement for O2
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
requirement for O2
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
semidehydroascorbate
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
peptidylglycine alpha-hydroxylating monooxygenase reaction
the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
2 Cu2+, A and B, are involved in the catalytic reaction
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
C-H bond cleavage is irreversible, activation of molecular O2 and of the C-H bond of the substrate, mechanism, reductive activation of Cu(II)-OOH to generate a reactive copper-oxo species
-
-
ir
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
formation of a CuIIM-OOH intermediate, intramolecular electron transfer
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
peptidylglycine alpha-hydroxylating monooxygenase reaction, diverse glycine derivatives or substitutes
the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
the enzyme catalyzes the final reaction in the maturation of alpha-amidated peptide hormones
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
-
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
requirement for O2
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
diverse synthetic substrates with C-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
peptidylglycine + ascorbate + O2
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
COOH-terminal glycine
-
?
proopiomelanocortin peptide + ascorbate + O2
proopiomelanocortin peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
a POMC 18-kDa fragment
-
-
?
proopiomelanocortin peptide + ascorbate + O2
proopiomelanocortin peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
a POMC 18-kDa fragment, establishment of an assay method
-
-
?
proopiomelanocortin peptide + ascorbate + O2
proopiomelanocortin peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
a POMC 18-kDa fragment
-
-
?
proopiomelanocortin peptide + ascorbate + O2
proopiomelanocortin peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
a POMC 18-kDa fragment, establishment of an assay method
-
-
?
R-CO-NH-CH2-COOH + ascorbate + O2
R-CO-NH2 + CHO-COOH + dehydroascorbate + H2O
-
-
-
-
?
R-CO-NH-CH2-COOH + ascorbate + O2
R-CO-NH2 + CHO-COOH + dehydroascorbate + H2O
-
via hydroxylated reaction intermediates
-
-
?
additional information
?
-
-
EC 1.14.17.3 is often called peptidylglycine alpha-amidating monooxygenase (PAM) and the alpha-amidated product is mentioned as the product of the reaction, but the alpha-amidation of glycine-extended peptides is a two-step process catalyzed by 2 enzymes: 1. EC 1.14.17.3: production of peptidyl(2-hydroxyglycine) by a copper, molecular oxygen and ascorbate-dependent peptidyl-glycine alpha-hydroxylating monooxygenase (PMH) and 2. conversion of the peptidyl-alpha-hydroxyglycine derivative into an alpha-amidated product at physiological pH by peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
-
?
additional information
?
-
-
EC 1.14.17.3 is often called peptidylglycine alpha-amidating monooxygenase (PAM) and the alpha-amidated product is mentioned as the product of the reaction, but the alpha-amidation of glycine-extended peptides is a two-step process catalyzed by 2 enzymes: 1. EC 1.14.17.3: production of peptidyl(2-hydroxyglycine) by a copper, molecular oxygen and ascorbate-dependent peptidyl-glycine alpha-hydroxylating monooxygenase (PMH) and 2. conversion of the peptidyl-alpha-hydroxyglycine derivative into an alpha-amidated product at physiological pH by peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
-
?
additional information
?
-
-
acetyl-L-Phe-Gly, acetyl-L-Phe-L-Phe-Gly, or (S)-O-acetyl-mandelyl-Gly, and stereoisomers are alpha-hydroxylated but not alpha-amidated
-
-
?
additional information
?
-
-
PAM catalyzes: 1. sulfoxidation of e.g. (4-nitrobenzyl) thioacetic acid to the analogous sulfoxide, 2. amine N-dealkylation of e.g. N-(4-nitrobenzyl)glycine to 4-nitrobenzylamine and glyoxylate, 3. O-dealkylation of e.g. [(4-nitrobenzyl)oxy]acetic acid to 4-nitrobenzyl alcohol and glyoxylate, 4. transformation of hippuric acid and several ring-substituted derivatives to the corresponding benzoamides and glyoxylic acid
-
-
?
additional information
?
-
-
PAM carries out two functions, peptidyl alpha-hydroxylating monooxygenase and peptidylamido-glycolate lyase activities
-
-
?
additional information
?
-
-
PAM carries out two functions, peptidyl alpha-hydroxylating monooxygenase and peptidylamido-glycolate lyase activities
-
-
?
additional information
?
-
C-terminally amidation of a range of peptides by the copper-dependent enzyme, peptidylglycine alpha-amidating monooxygenase, PAM. PAM-dependent amidation of POMC peptides in AtT20 cells
-
-
?
additional information
?
-
enzyme is required for amidation of the C-terminus of neuropeptides
-
-
?
additional information
?
-
-
at alkaline pH spontaneous conversion
-
-
?
additional information
?
-
-
EC 1.14.17.3 is often called peptidylglycine alpha-amidating monooxygenase (PAM) and the alpha-amidated product is mentioned as the product of the reaction, but the alpha-amidation of glycine-extended peptides is a two-step process catalyzed by 2 enzymes: 1. EC 1.14.17.3: production of peptidyl(2-hydroxyglycine) by a copper, molecular oxygen and ascorbate-dependent peptidyl-glycine alpha-hydroxylating monooxygenase (PMH) and 2. conversion of the peptidyl-alpha-hydroxyglycine derivative into an alpha-amidated product at physiological pH by peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
-
?
additional information
?
-
-
enzyme is required for amidation of autocrine growth factors causing proliferation in tumor cells
-
-
?
additional information
?
-
-
PHM replaces the pro-(S) hydrogen of the carboxy-terminal glycine with a hydroxyl group to form an alpha-hydroxyglycine intermediate
-
-
?
additional information
?
-
-
the enzyme peptidylglycine alpha-amidating monooxygenase consists of two subunits: peptidylglycine alpha-hydroxylating monooxygenase that initiates formation of a radical at a substrate's C-terminal glycine alpha-carbon to then give an alpha-hydroxylated glycine derivative, and peptidylamidoglycolate lyase which catalyzes cleavage of this hydroxyglycine intermediate to give the amidated product with consequent release of glyoxylate
-
-
?
additional information
?
-
C-terminally amidation of a range of peptides by the copper-dependent enzyme, peptidylglycine alpha-amidating monooxygenase, PAM
-
-
?
additional information
?
-
constitutive-like secretion of POMC products in recombinant enzyme-expressing cells
-
-
?
additional information
?
-
-
enzyme is involved in peptide posttranslational activation
-
-
?
additional information
?
-
-
PAM is the only enzyme capable of amidating peptides, amidated peptides are numerous
-
-
?
additional information
?
-
C-terminally amidation of a range of peptides by the copper-dependent enzyme, peptidylglycine alpha-amidating monooxygenase, PAM
-
-
?
additional information
?
-
-
substrate specificity
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
cleavage of C-H bond in the second reaction step is irreversible
-
-
?
additional information
?
-
-
endorphins are inhibitory substrates
-
-
?
additional information
?
-
-
EC 1.14.17.3 is often called peptidylglycine alpha-amidating monooxygenase (PAM) and the alpha-amidated product is mentioned as the product of the reaction, but the alpha-amidation of glycine-extended peptides is a two-step process catalyzed by 2 enzymes: 1. EC 1.14.17.3: production of peptidyl(2-hydroxyglycine) by a copper, molecular oxygen and ascorbate-dependent peptidyl-glycine alpha-hydroxylating monooxygenase (PMH) and 2. conversion of the peptidyl-alpha-hydroxyglycine derivative into an alpha-amidated product at physiological pH by peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
-
?
additional information
?
-
-
EC 1.14.17.3 is often called peptidylglycine alpha-amidating monooxygenase (PAM) and the alpha-amidated product is mentioned as the product of the reaction, but the alpha-amidation of glycine-extended peptides is a two-step process catalyzed by 2 enzymes: 1. EC 1.14.17.3: production of peptidyl(2-hydroxyglycine) by a copper, molecular oxygen and ascorbate-dependent peptidyl-glycine alpha-hydroxylating monooxygenase (PMH) and 2. conversion of the peptidyl-alpha-hydroxyglycine derivative into an alpha-amidated product at physiological pH by peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
-
?
additional information
?
-
-
EC 1.14.17.3 is often called peptidylglycine alpha-amidating monooxygenase (PAM) and the alpha-amidated product is mentioned as the product of the reaction, but the alpha-amidation of glycine-extended peptides is a two-step process catalyzed by 2 enzymes: 1. EC 1.14.17.3: production of peptidyl(2-hydroxyglycine) by a copper, molecular oxygen and ascorbate-dependent peptidyl-glycine alpha-hydroxylating monooxygenase (PMH) and 2. conversion of the peptidyl-alpha-hydroxyglycine derivative into an alpha-amidated product at physiological pH by peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
-
?
additional information
?
-
-
substrates are also physiologically relevant peptides related to alpha-melanotropine
-
-
?
additional information
?
-
-
tunneling of hydrogen ion, relatively flexible
-
-
?
additional information
?
-
-
cleavage of CN bond in N-acetylated glycines, R-CO-NH-CH2-COOH, e.g. found in neuropeptide prohormones, inhibition of the enzyme leads to a decrease in alpha-aminated peptide production and accumulation of glycine-extended precursors
-
-
?
additional information
?
-
-
enzyme catalyzes the biosynthesis of peptide hormones through radical cleavage of the C-terminal glycine residues of the corresponding prohormones
-
-
?
additional information
?
-
-
enzyme catalyzes the production of neurohormones and neurotransmitters
-
-
?
additional information
?
-
-
enzyme is involved in peptide posttranslational activation
-
-
?
additional information
?
-
-
enzyme is required for amidation of autocrine growth factors causing proliferation in tumor cells
-
-
?
additional information
?
-
-
enzyme might be involved in secretory vesicle budding and fusion in the cardiac ANP-secretory pathway
-
-
?
additional information
?
-
-
substrate specificity, cleavage of CN bond in N-acetylated glycines, R-CO-NH-CH2-COOH, e.g. found in neuropeptide prohormones
-
-
?
additional information
?
-
-
substrate specificity, effects of substitutions on the glycine substrate, overview
-
-
?
additional information
?
-
-
long distance electron-transfer mechanism between the two distant copper cations, a perfect fitting for a water bridge, molecular dynamics simulations using wild-type and mutant enzymes, overview
-
-
?
additional information
?
-
-
PAM is the rate-limiting enzyme for the generation of carboxy-terminal alpha-amidated neuropeptides
-
-
?
additional information
?
-
constitutive-like secretion of POMC products in recombinant enzyme-expressing cells
-
-
?
additional information
?
-
peptidylglycine alpha-hydroxylating monooxygenase (PHM) catalyzes stereospecific alpha-C hydroxylation of C-terminal glycines, the first step in the alpha-amidation of hormones, growth factors and neurotransmitters. The molecular oxygen-dependent reaction requires two equivalents of ascorbate as exogenous reductant, releasing water and semidehydroascorbate as byproducts
-
-
?
additional information
?
-
-
substrates are also physiologically relevant peptides related to alpha-melanotropine
-
-
?
additional information
?
-
-
substrates are also physiologically relevant peptides related to alpha-melanotropine
-
-
?
additional information
?
-
-
EC 1.14.17.3 is often called peptidylglycine alpha-amidating monooxygenase (PAM) and the alpha-amidated product is mentioned as the product of the reaction, but the alpha-amidation of glycine-extended peptides is a two-step process catalyzed by 2 enzymes: 1. EC 1.14.17.3: production of peptidyl(2-hydroxyglycine) by a copper, molecular oxygen and ascorbate-dependent peptidyl-glycine alpha-hydroxylating monooxygenase (PMH) and 2. conversion of the peptidyl-alpha-hydroxyglycine derivative into an alpha-amidated product at physiological pH by peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
-
?
additional information
?
-
-
EC 1.14.17.3 is often called peptidylglycine alpha-amidating monooxygenase (PAM) and the alpha-amidated product is mentioned as the product of the reaction, but the alpha-amidation of glycine-extended peptides is a two-step process catalyzed by 2 enzymes: 1. EC 1.14.17.3: production of peptidyl(2-hydroxyglycine) by a copper, molecular oxygen and ascorbate-dependent peptidyl-glycine alpha-hydroxylating monooxygenase (PMH) and 2. conversion of the peptidyl-alpha-hydroxyglycine derivative into an alpha-amidated product at physiological pH by peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
-
?
additional information
?
-
-
EC 1.14.17.3 is often called peptidylglycine alpha-amidating monooxygenase (PAM) and the alpha-amidated product is mentioned as the product of the reaction, but the alpha-amidation of glycine-extended peptides is a two-step process catalyzed by 2 enzymes: 1. EC 1.14.17.3: production of peptidyl(2-hydroxyglycine) by a copper, molecular oxygen and ascorbate-dependent peptidyl-glycine alpha-hydroxylating monooxygenase (PMH) and 2. conversion of the peptidyl-alpha-hydroxyglycine derivative into an alpha-amidated product at physiological pH by peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
-
?
additional information
?
-
-
EC 1.14.17.3 is often called peptidylglycine alpha-amidating monooxygenase (PAM) and the alpha-amidated product is mentioned as the product of the reaction, but the alpha-amidation of glycine-extended peptides is a two-step process catalyzed by 2 enzymes: 1. EC 1.14.17.3: production of peptidyl(2-hydroxyglycine) by a copper, molecular oxygen and ascorbate-dependent peptidyl-glycine alpha-hydroxylating monooxygenase (PMH) and 2. conversion of the peptidyl-alpha-hydroxyglycine derivative into an alpha-amidated product at physiological pH by peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
-
?
additional information
?
-
-
EC 1.14.17.3 is often called peptidylglycine alpha-amidating monooxygenase (PAM) and the alpha-amidated product is mentioned as the product of the reaction, but the alpha-amidation of glycine-extended peptides is a two-step process catalyzed by 2 enzymes: 1. EC 1.14.17.3: production of peptidyl(2-hydroxyglycine) by a copper, molecular oxygen and ascorbate-dependent peptidyl-glycine alpha-hydroxylating monooxygenase (PMH) and 2. conversion of the peptidyl-alpha-hydroxyglycine derivative into an alpha-amidated product at physiological pH by peptidyl-alpha-hydroxyglycine alpha-amidating lyase
-
-
?
additional information
?
-
-
peptide alpha-amidation, enzyme is responsible for formation of peptide C-terminal amide
-
-
?
additional information
?
-
-
peptide alpha-amidation, the N-terminal substrate structure affects the interaction with the active site of the enzyme
-
-
?