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1.14.17.3: peptidylglycine monooxygenase

This is an abbreviated version!
For detailed information about peptidylglycine monooxygenase, go to the full flat file.

Word Map on EC 1.14.17.3

Reaction

[peptide]-glycine
+ 2 ascorbate +
O2
=
[peptide]-(2S)-2-hydroxyglycine
+ 2 monodehydroascorbate +
H2O

Synonyms

alpha-AE, bifunctional PAM, bifunctional peptidylglycine alpha-amidating monooxygenase, CG3832, hPHMcc, More, PAM, PAM-1, PAM-2, PAM-A, PAM-B, PAM/PHM, peptide alpha-amidating enzyme, peptide alpha-amide synthase, peptide-alpha-amide synthetase, peptidyl alpha-amidating enzyme, peptidyl alpha-hydroxylating monooxygenase, peptidyl-glycine alpha-amidating monooxygenase, peptidylglycine 2-hydroxylase, peptidylglycine alpha-amidating mono-oxygenase, peptidylglycine alpha-amidating monooxygenase, peptidylglycine alpha-hydroxylase, peptidylglycine alpha-hydroxylating monooxygenase, peptidylglycine alpha-hydroxylating-monooxygenase, peptidylglycine alpha-monooxygenase, peptidylglycine monooxygenase, peptidylglycine-alpha-amidating monooxygenase, PHM, PHMcc, synthase, peptide alpha-amide, type A PAM

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.17.3 peptidylglycine monooxygenase

KI Value

KI Value on EC 1.14.17.3 - peptidylglycine monooxygenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.44
(2E)-4-oxo-4-phenylbut-2-enoic acid
-
pH 6.5, 37°C
0.015
(3E)-4-(4-methoxyphenyl)but-3-enoic acid
-
pH 6.5, 37°C
0.0057
(3E)-4-(4-methylphenyl)but-3-enoic acid
-
pH 6.5, 37°C
0.0039
(3E)-4-[3-(benzyloxy)-4-methoxyphenyl]but-3-enoic acid
-
pH 6.5, 37°C
0.019
(3E)-4-[4-(benzyloxy)phenyl]but-3-enoic acid
-
pH 6.5, 37°C
7.9
(CBZ-hydrazido)glycine
Ki,s
75
(nicotinamidomethyl)phosphonic acid
Ki,s, larger than 75
0.06
(R)-5-acetamido-4-oxo-6-phenyl-2-hexenoic acid
-
pH 6.5, 37°C
0.054
(S)-5-acetamido-4-oxo-6-phenyl-2-hexenoic acid
-
pH 6.5, 37°C
0.057
(S)-5-acetamido-7-methylthio-4-oxo-2-heptenoic acid
-
pH 6.5, 37°C
1.4
(S)-N-CBZ-4-amino-2-hydroxybutyric acid
Ki,s
0.2
2-trifluoromethylcinnamic acid
37°C, pH 6.0
0.3
3,4-methylenedioxycinnamic acid
37°C, pH 6.0
6
3-(3-pyridyl)acrylic acid
37°C, pH 6.0
2.9
3-benzoylpropionic acid
Ki,s
0.5
4-aminocinnamic acid
37°C, pH 6.0
0.6
4-nitrocinnamic acid
37°C, pH 6.0
0.001 - 0.019
4-Phenyl-3-butenoic acid
0.0034 - 0.0057
4-phenylbut-3-enoic acid
0.035
6-O-palmitoyl-L-ascorbate
Ki,s
2.11
acetyl-D-Leu-OCH2COOH
-
-
1.3
acetyl-D-Phe-Gly
-
-
2.25
acetyl-D-Phe-OCH2COOH
-
-
0.522
acetyl-DL-Phe-OCH2COOH
-
-
1.25
acetyl-Gly-OCH2COOH
-
-
0.0598
acetyl-L-Leu-OCH2COOH
-
-
0.58
acetyl-L-Phe-D-Phe-Gly
-
-
0.002
acetyl-L-Phe-Gly
-
-
0.045
acetyl-L-Phe-OCH2COOH
-
-
0.005
adrenocorticotrophic hormone (1-10)
-
-
0.001
alpha-N-acetyl-adrenocorticotrophic hormone(1-14)
-
-
4
Cinnamic acid
37°C, pH 6.0
0.00113 - 0.00119
diethyldithiocarbamate
0.00051 - 0.00065
Disulfiram
0.0006
endorphin(51-61)NH2
-
-
-
0.066
glutathione ethyl ester
Ki,s
0.015
glyoxylate phenylhydrazone
-
-
0.11
glyoxylate thiosemicarbazone
-
-
2.9 - 22
hippuric acid
1.3
Monoethyl fumarate
-
-
3
N,N-dimethyl-4-aminocinnamic acid
37°C, pH 6.0
0.069
N,S-dibenzoyl-L-cysteine
Ki,s
1.5
N-(benzoyl)-D-serine
Ki,s
0.0072
N-(thiobenzoyl)-(D,L)-alanine
Ki,s
2.1
N-acetyl-D-Leu-OCH2COOH
-
pH not specified in the publication, temperature not specified in the publication
1.3
N-acetyl-D-Phe-Gly
-
pH not specified in the publication, temperature not specified in the publication
0.0598
N-acetyl-L-Leu-OCH2COOH
-
pH not specified in the publication, temperature not specified in the publication
0.0452
N-acetyl-L-Phe-OCH2COOH
-
pH not specified in the publication, temperature not specified in the publication
18
N-benzylglycine
Ki,s
0.01
N-dansyl-4-aminocinnamic acid
37°C, pH 6.0
0.11
N-phenylthiohydantoic acid
Ki,s
0.054
O-(phenylcarbamoyl)glycolic acid
Ki,s
8.1
O-acetyl-D-mandelyl-Gly
-
pH not specified in the publication, temperature not specified in the publication
1
O-benzamidoglycolic acid
Ki,s
4
perdeuterated cinnamic acid
37°C, pH 6.0
2
phenylpropionic acid
37°C, pH 6.0
1
Pro-Leu-Gly hydroxamic acid
Ki,s
0.0079
S-(2-phenylthioacetyl)thioglycolic acid
Ki,s
0.0094
S-(3-phenylthiopropionyl)thioglycolic acid
Ki,s
0.0035
S-(4-methylthiobenzoyl)thioglycolic acid
Ki,s
0.11
S-(4-methylthiobenzoyl)thioglycolic acid ethyl ester
Ki,s
0.0026
S-(phenylthiocarbamoyl)-3-mercaptopropionic acid
Ki,s
0.0086
S-(phenylthiocarbamoyl)thioglycolic acid
Ki,s
0.058
S-(thiobenzoyl)-(R,S)-thiolactic acid
Ki,s
0.0057
S-(thiobenzoyl)-4-mercapto-4-cyanopentanoic acid
Ki,s
0.039
S-(thiobenzoyl)thioglycolic acid
Ki,s
0.00054
S-(thiolauroyl)thioglycolic acid
Ki,s
0.38
S-phenylmercaptoacetic acid
Ki,s
0.3
Salicylhydroxamic acid
Ki,s
0.16
trans-Benzoylacrylic acid
-
-
0.131
[(1R,2S)-2-phenylcyclopropyl]acetic acid
-
pH 6.5, 37°C
0.48
[(4-Methoxybenzoyl)oxy]acetic acid
-
-