1.14.17.1: dopamine beta-monooxygenase

This is an abbreviated version!
For detailed information about dopamine beta-monooxygenase, go to the full flat file.

Word Map on EC 1.14.17.1

Reaction

dopamine
+
ascorbate
+
O2
=
noradrenaline
+
dehydroascorbate
+
H2O

Synonyms

3,4-dihydroxy-phenylethylamine, ascorbate: oxygen oxidoreductase (3-hydroxylating), 3,4-dihydroxyphenethylamine beta-oxidase, 3,4-dihydroxyphenylethylamine beta-hydoxylase, 4-(2-aminoethyl)pyrocatechol beta-oxidase, DbetaH, DbetaM, DBH, DBM, Dopa beta-hydroxylase, dopamine beta hydroxylase, dopamine beta-hydrolase, dopamine beta-hydroxylase, dopamine beta-mono-oxygenase, dopamine beta-monooxygenase, dopamine beta-oxidase, dopamine hydroxylase, dopamine(3,4-dihydroxyphenethylamine)beta-mono-oxygenase, dopamine-B-hydroxylase, dopamine-beta hydroxylase, dopamine-beta-hydroxylase, dopamine-beta-monooxygenase, EC 1.14.2.1, gDBH, LvDBH, MDBH, oxygenase, dopamine beta-mono-, pDbetaH, phenylamine beta-hydroxylase, plasma DbetaH activity, plasma dopamine beta-hydroxylase, plDbetaH, SDBH, TBetaM, tyramine beta-monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.17.1 dopamine beta-monooxygenase

KI Value

KI Value on EC 1.14.17.1 - dopamine beta-monooxygenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0057
1(2H)-Phthalazine hydrazone
-
-
4.6
1-(3,4-Dihydroxybenzyl)imidazole
-
-
2.9
1-(4-Hydroxybenzyl)-2-methylimidazole
-
-
0.16
1-(4-Hydroxybenzyl)pyrazole
-
-
11.9
1-Benzylimidazole
-
-
0.0009 - 0.8
1-Isoquinolinecarboxylic acid
13
1-Phenyl-1-aminomethylethene
-
-
2.5
1-Phenylpropene
-
-
0.0019
2(1H)-Pyridinone hydrazone
-
-
0.021
2,2'-Bi-(1H)-imidazole
-
-
0.52
2-(4-Hydroxyphenyl)prop-2-enylamine
-
-
4.9
2-Bromo-3-(p-hydroxyphenyl)-1-propene
-
-
4.7
2-Phenylprop-2-enylamine
-
-
3.6
3-Phenylpropene
-
-
2.5
4-Hydroxy-alpha-methylstyrene
-
-
2.3
4-hydroxybenzaldehyde
-
-
0.0011 - 20
ascorbate
1.25 - 7.8
beta,beta-dideuterated tyramine
26
beta,beta-difluorophenethylamine
-
pH 6.0, 35C
0.015 - 0.208
beta-ethynytyramine
0.41
histidine
-
-
0.37 - 1.05
hydroquinone
6.8
N-ethylaniline
-
-
1.1
N-Phenylethylenediamine
-
-
5
norepinephrine
-
-
0.14
Quinoline-2-carboxylic acid
-
-
0.98 - 10.3
tyramine
additional information
additional information
-