1.14.16.7: phenylalanine 3-monooxygenase

This is an abbreviated version, for detailed information about phenylalanine 3-monooxygenase, go to the full flat file.

Reaction

L-phenylalanine
+
tetrahydrobiopterin
+
O2
=
3-hydroxy-L-phenylalanine
+
4a-hydroxytetrahydrobiopterin

Synonyms

PacX, phenylalanine 3-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.7 phenylalanine 3-monooxygenase

Substrates Products

Substrates Products on EC 1.14.16.7 - phenylalanine 3-monooxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-phenylalanine + 6-methyltetrahydropterin + O2
3-hydroxy-L-phenylalanine + 4a-hydroxy-6-methyltetrahydropterin
show the reaction diagram
-
-
-
?
L-phenylalanine + tetrahydrobiopterin + O2
3-hydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin
show the reaction diagram
the enzyme forms 3-hydroxy-L-phenylalanine (i.e. m-L-tyrosine) which is one of the building blocks in the biosynthesis of pacidamycins
3-hydroxy-L-phenylalanine i.e. m-L-Tyr
-
?
additional information
?
-
no activity with D-Phe, L-Tyr, and L-Trp
-
-
-