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1.14.16.4: tryptophan 5-monooxygenase

This is an abbreviated version!
For detailed information about tryptophan 5-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.4

Reaction

L-tryptophan
+
a 5,6,7,8-tetrahydropteridine
 +
O2
=
5-hydroxy-L-tryptophan
 +
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

hTPH2, indoleacetic acid-5-hydroxylase, L-tryptophan 5-hydroxylase, L-tryptophan hydroxylase, oxygenase, tryptophan 5-mono-, peripheral tryptophan hydroxylase, PTMO, putative tryptophan monooxygenase, TH2, TPH, TPH-1, TPH-2, TPH1, TPH2, TRpOH, tryptophan 5-hydroxylase, tryptophan 5-monooxygenase, tryptophan hydroxylase, tryptophan hydroxylase 1, tryptophan hydroxylase 2, tryptophan hydroxylase I, tryptophan hydroxylase isoform 1, tryptophan hydroxylase isoform 2, tryptophan hydroxylase isoform2, tryptophan hydroxylase type I, tryptophan hydroxylase-1, tryptophan hydroxylase-2, tryptophan-5-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.4 tryptophan 5-monooxygenase

Specific Activity

Specific Activity on EC 1.14.16.4 - tryptophan 5-monooxygenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000018
-
enzyme from carconoid tumor
0.000064
recombinant mutant R441H TPH2 in HEK-293 cells
0.00018
-
partially purified enzyme from hindbrain
0.00052
recombinant wild-type TPH2 in HEK-293 cells
0.00165
recombinant mutant P449R TPH2 in HEK-293 cells
0.0021
-
hindbrain enzyme
0.0144
-
purified recombinant enzyme, pH and temperature not specified in the publication
0.0214
-
TPH expressed in Pichia pastoris
0.0271
-
brain tryptophan hydroxylase
0.045
-
brain tryptophan hydroxylase
0.082
-
tryptophan hydroxylase form II
0.17
recombinant His-tagged enzyme
0.235
-
tryptophan hydroxylase from pineal gland
0.296
-
TPH as fusion protein with maltose-binding protein expressed in Escherichia coli
0.367
0.374
0.434
-
recombinant enzyme, activity in cell extracts
13.3
-
liver enzyme
additional information