1.14.16.4: tryptophan 5-monooxygenase

This is an abbreviated version!
For detailed information about tryptophan 5-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.4

Reaction

L-tryptophan
+
tetrahydrobiopterin
+
O2
=
5-hydroxy-L-tryptophan
+
4a-hydroxytetrahydrobiopterin

Synonyms

hTPH2, indoleacetic acid-5-hydroxylase, L-tryptophan 5-hydroxylase, L-tryptophan hydroxylase, oxygenase, tryptophan 5-mono-, peripheral tryptophan hydroxylase, PTMO, putative tryptophan monooxygenase, TH2, TPH, TPH-1, TPH-2, TPH1, TPH2, TRpOH, tryptophan 5-hydroxylase, tryptophan 5-monooxygenase, tryptophan hydroxylase, tryptophan hydroxylase 1, tryptophan hydroxylase 2, tryptophan hydroxylase I, tryptophan hydroxylase isoform 1, tryptophan hydroxylase isoform 2, tryptophan hydroxylase isoform2, tryptophan hydroxylase type I, tryptophan hydroxylase-1, tryptophan hydroxylase-2, tryptophan-5-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.4 tryptophan 5-monooxygenase

Sequence

Sequence on EC 1.14.16.4 - tryptophan 5-monooxygenase

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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
PH4H_CAEEL
457
0
52129
Swiss-Prot
PH4H_DICDI
441
0
50415
Swiss-Prot
PH4H_DROME
452
0
51660
Swiss-Prot
TPH1_CHICK
445
0
51139
Swiss-Prot
TPH1_HUMAN
444
0
50985
Swiss-Prot
TPH1_MOUSE
447
0
51343
Swiss-Prot
TPH1_RABIT
444
0
51118
Swiss-Prot
TPH1_RAT
444
0
51068
Swiss-Prot
TPH2_HORSE
491
0
56087
Swiss-Prot
TPH2_HUMAN
490
0
56057
Swiss-Prot
TPH2_MACMU
490
0
56095
Swiss-Prot
TPH2_MOUSE
488
0
55859
Swiss-Prot
TPH2_RAT
485
0
55621
Swiss-Prot
TPH_XENLA
481
0
55406
Swiss-Prot
E0VT41_PEDHC
Pediculus humanus subsp. corporis
182
1
21032
TrEMBL
V4ZA37_TOXGV
Toxoplasma gondii (strain ATCC 50861 / VEG)
210
0
22644
TrEMBL
S7UPG2_TOXGG
Toxoplasma gondii (strain ATCC 50853 / GT1)
217
0
23372
TrEMBL
D5HB02_SALRM
Salinibacter ruber (strain M8)
278
0
32122
TrEMBL
A0A2T6IDD8_TOXGO
309
0
35134
TrEMBL
Q8K3R1_MESAU
446
0
51042
TrEMBL
B7PLQ7_IXOSC
157
0
17767
TrEMBL
E7BTQ2_CLAGA
487
0
56069
TrEMBL
A1Y9J6_CIOIN
448
0
50577
TrEMBL
D4HNR5_ORENI
461
0
52661
TrEMBL
S8ETY4_TOXGM
Toxoplasma gondii (strain ATCC 50611 / Me49)
569
0
62944
TrEMBL
A0A191Y1Z8_RACCA
480
0
55202
TrEMBL
A0A139XII3_TOXGO
568
0
62749
TrEMBL
A0A0J9RMW1_DROSI
555
0
61530
TrEMBL
O96370_SCHMA
497
0
57599
TrEMBL
A0A061HWP4_CRIGR
108
0
11625
TrEMBL
B4KWR4_DROMO
565
0
62743
TrEMBL
E0VZU7_PEDHC
Pediculus humanus subsp. corporis
484
0
54743
TrEMBL
C7TY28_SCHJA
420
0
48995
TrEMBL
C1LDI3_SCHJA
337
0
39386
TrEMBL
B7PQJ7_IXOSC
114
0
12847
TrEMBL
B7P4Z5_IXOSC
446
0
50757
TrEMBL
B4PCR3_DROYA
558
0
61776
TrEMBL
F4H0V0_CELFA
Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547)
295
0
32764
TrEMBL
E0VT40_PEDHC
Pediculus humanus subsp. corporis
433
0
49519
TrEMBL
B3VBV0_MICUN
487
0
55936
TrEMBL