1.14.16.4: tryptophan 5-monooxygenase

This is an abbreviated version!
For detailed information about tryptophan 5-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.4

Reaction

L-tryptophan
+
tetrahydrobiopterin
+
O2
=
5-hydroxy-L-tryptophan
+
4a-hydroxytetrahydrobiopterin

Synonyms

hTPH2, indoleacetic acid-5-hydroxylase, L-tryptophan 5-hydroxylase, L-tryptophan hydroxylase, oxygenase, tryptophan 5-mono-, peripheral tryptophan hydroxylase, PTMO, putative tryptophan monooxygenase, TH2, TPH, TPH-1, TPH-2, TPH1, TPH2, TRpOH, tryptophan 5-hydroxylase, tryptophan 5-monooxygenase, tryptophan hydroxylase, tryptophan hydroxylase 1, tryptophan hydroxylase 2, tryptophan hydroxylase I, tryptophan hydroxylase isoform 1, tryptophan hydroxylase isoform 2, tryptophan hydroxylase isoform2, tryptophan hydroxylase type I, tryptophan hydroxylase-1, tryptophan hydroxylase-2, tryptophan-5-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.4 tryptophan 5-monooxygenase

KM Value

KM Value on EC 1.14.16.4 - tryptophan 5-monooxygenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.045
(6R)-5,6,7,8-tetrahydrobiopterin
-
substrate tryptophan
0.0128 - 0.281
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin
0.01789 - 0.796
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin
2.1
(7R)-5,6,7,8-tetrahydrobiopterin
-
substrate tryptophan
0.006 - 0.13
2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine
0.05
2-amino-4-hydroxy-6-methyl-5,6,7,8-tetrahydropteridine
-
-
0.055 - 0.125
2-amino-4-hydroxy-6-methyltetrahydropteridine
0.0865
2-azaisotryptophan
-
-
0.262
4-azatryptophan
-
-
0.994
4-methyltryptophan
-
-
0.295
6-azatryptophan
-
-
0.075
6-methyl-5,6,7,8-tetrahydrobiopterin
-
substrate tryptophan
0.053 - 0.802
6-methyl-tetrahydropterin
0.0146 - 0.177
6-methyltetrahydropterin
0.0151
6-methyltryptophan
-
-
0.0662
7-azatryptophan
-
-
0.0375
7-methyltryptophan
-
-
0.022 - 0.102
L-phenylalanine
0.002 - 0.355
L-tryptophan
0.039 - 0.273
O2
0.09 - 0.286
phenylalanine
0.0067 - 0.324
tetrahydrobiopterin
0.05 - 0.29
tryptophan
additional information
additional information
-