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1.14.15.8: steroid 15beta-monooxygenase

This is an abbreviated version!
For detailed information about steroid 15beta-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.8

Reaction

progesterone
+
reduced ferredoxin
 +
O2
 +
H+
=
15beta-hydroxyprogesterone
 +
oxidized ferredoxin
 +
H2O

Synonyms

15beta-hydroxylase, 15beta-hydroxylase CYP106A2, BmCYP106A2, Cyp106A1, CYP106A2, cytochrome P-450meg, cytochrome P450meg, steroid-15-beta-monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.8 steroid 15beta-monooxygenase

Crystallization

Crystallization on EC 1.14.15.8 - steroid 15beta-monooxygenase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
to 2.7 A resolution. The alpha8–alpha9 loop region is intrinsically mobile and might be important for initial ligand binding
Bacillus sp. PAMC 23377
-
substrate-free enzyme to 1.8 A resolution, cocrystallization of CYP106A2 with abietic acid reveals bending of the heme cofactor when abietic acid is bound in the active site