1.14.15.5: corticosterone 18-monooxygenase
This is an abbreviated version!
For detailed information about corticosterone 18-monooxygenase, go to the full flat file.
Word Map on EC 1.14.15.5
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1.14.15.5
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aldosterone
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18-hydroxycorticosterone
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steroid
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cyp11b2
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glomerulosa
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cortisol
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hypoaldosteronism
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zona
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thrive
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acth
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hyperkalemia
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renin
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18-hydroxylation
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salt-wasting
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mineralocorticoid
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fasciculata
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11-deoxycorticosterone
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18-hydroxycortisol
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18-oh-corticosterone
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fludrocortisone
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salt-losing
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18-oxocortisol
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furosemide
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p450aldo
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deoxycorticosterone
- 1.14.15.5
- aldosterone
- 18-hydroxycorticosterone
- steroid
- cyp11b2
-
glomerulosa
- cortisol
- hypoaldosteronism
- zona
-
thrive
- acth
-
hyperkalemia
- renin
-
18-hydroxylation
-
salt-wasting
-
mineralocorticoid
-
fasciculata
- 11-deoxycorticosterone
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18-hydroxycortisol
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18-oh-corticosterone
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fludrocortisone
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salt-losing
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18-oxocortisol
- furosemide
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p450aldo
- deoxycorticosterone
Reaction
+ 2 reduced adrenodoxin + + 2 H+ = + 2 oxidized adrenodoxin +
Synonyms
corticosterone 18-hydroxylase, corticosterone methyl oxidase, CYP11B2, cytochrome P450 11B2, oxygenase, corticosterone 18-mono-
ECTree
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Engineering
Engineering on EC 1.14.15.5 - corticosterone 18-monooxygenase
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V386A
the combination of the V386A mutation with the variant CYP11B2 173Arg only slightly reduces the 18-hydroxylase and 18-oxidase activity, whereas the V386A mutation with the CYP11B2 173Lys variant almost abolishes the 18-hydroxylation and 18-oxidation. In both cases the 11-hydroxylase activity is not affected