1.14.15.4: steroid 11beta-monooxygenase

This is an abbreviated version!
For detailed information about steroid 11beta-monooxygenase, go to the full flat file.

Reaction

Synonyms

11
-hydroxylase, 11 beta-hydroxylase, 11-beta hydroxylase, 11-beta-hydroxylase, 11-hydroxylase, 11beta hydroxylase, 11beta-hydroxylase, ALDOS, Aldosterone synthase, Aldosterone-synthesizing enzyme, C450XIB2, CYP11B1, CYP11B2, cyp11beta, CYPXIB, CYPXIB1, CYPXIB2, CYPXIB3, cytochrome 11beta-hydroxylase, cytochrome P-45011-beta, cytochrome P450 11B1, cytochrome P450 11B2, cytochrome P450 11beta-hydroxylase, cytochrome P45011beta, cytochrome P45011beta-hydroxylase, EC 1.14.1.6, EC 1.99.1.7, P-450(11 beta,aldo), P-450Aldo, P-450c11, P-450C18, P-450XIB1, P450 11beta-hydroxylase, P450(11 beta)-DS, P45011beta, P450C11, Steroid 11-beta-hydroxylase, steroid 11-hydroxylase, steroid 11beta-hydroxylase, steroid 11beta-monooxygenase, steroid 11beta/18-hydroxylase, Steroid 18-hydroxylase, steroid-11beta-hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.15.4 steroid 11beta-monooxygenase

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Results	in table
14	Activating Compound
138	AA Sequence
9	Application
1	CAS Registry Number
36	Cloned(Commentary)
53	Cofactor
1	Crystallization (Commentary)
4812	Disease/ Diagnostics
2	Expression
16	General Information
15	General Stability
213	IC50 Value
224	Inhibitors
4	Ki Value [mM]
27	KM Value [mM]
39	Localization
3	Metals/Ions
22	Molecular Weight [Da]
62	Natural Substrates/ Products (Substrates)
83	Organism
7	Pathway
60	PDB ID
26	pH Optimum
1	pH Range
35	Protein Variants
21	Purification (Commentary)
15	Reaction
4	Reaction Type
80	Reference
104	Source Tissue
31	Specific Activity [micromol/min/mg]
20	Storage Stability
138	Substrates and Products (Substrate)
20	Subunits
139	Synonyms
1	Systematic Name
26	Temperature Optimum [°C]
2	Temperature Range [°C]
7	Temperature Stability [°C]
11	Turnover Number [1/s]

Expression

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Expression on EC 1.14.15.4 - steroid 11beta-monooxygenase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

native very-low-density lipoprotein as well as glycoxidized VLDL, but not oxidized VLDL, mediate transcriptional upregulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways, e.g. partially through scavenger receptor class B type I. Very-low-density lipoprotein , irrespective of modification, presumably recruits PKA, ERK1/2 and Jak-2 for steroid hormone release through modulation of Cyp11B2 mRNA level

Homo sapiens

-

724701

stimulation of enzyme expression by the renin-angiotensin system, which takes 12 h to reach full effect, and then 24 h to subside

Homo sapiens

-

726012