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1.14.15.3: alkane 1-monooxygenase

This is an abbreviated version!
For detailed information about alkane 1-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.3

Reaction

Octane
+
reduced rubredoxin
 +
O2
 + 2 H+ =
1-Octanol
 +
oxidized rubredoxin
 +
H2O

Synonyms

1-hydroxylase, alkane 1-hydrolase, alkane hydroxylase, alkane mono-oxygenase, alkane monooxygenase, alkane omega-hydroxylase, alkane-1-monooxygenase 1, alkane-1-monooxygenase 2, AlkB, AlkB1, AlkB2, AlkW1, AlkW2, AlmA, AlmA-like alkane hydroxylase, BMO, butane monooxygenase, CYP omega hydroxylase, CYP omega-hydroxylase, Cyp153, CYP153 homologue, CYP153A, CYP153D17, CYP4 P450, CYP450 4A omega-hydroxylase, CYP450 omega-hydroxylase, CYP4A, CYP4A10, CYP4A11, CYP4A14, CYP4AII, CYP4d21, CYP86A1, CYP86B1, CYP94A1, CYPA11 P450, CYPIVA1, CYPIVA11, CYPIVA2, CYPIVA3, CYPIVA5, CYPIVA6, CYPIVA7, cytochrome P-450 omega-hydroxylase, cytochrome P450 alkane hydroxylase, cytochrome P450 omega hydroxylase, cytochrome P450-dependent fatty acid omega-hydroxylase, diiron omega-hydroxylase, FA omega-hydroxylase, fatty acid omega-hydrolase, Fatty acid omega-hydroxylase, Gpo1, hexane hydroxylase, Lauric acid omega-hydroxylase, MAH1-1, MAH1-2, male-specific fatty acid omega-hydroxylase, medium-chain alkane hydroxylase, methane monooxygenase, More, omega hydroxylase, omega-hydrolase, omega-hydroxylase, P-450 HK omega, P450-HL-omega, P452, Prm1ABCD, Prm2ABCD, propane monooxygenase, Rieske-type alkane monooxygenase, sex-specific enzyme 1, SXE1, UAM-Ps1, very long chain fatty acid hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.3 alkane 1-monooxygenase

Expression

Expression on EC 1.14.15.3 - alkane 1-monooxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
CYP4A gene is altered in both lipid and inflammatory disorders, modest 2fold induction of the CYP4A11 gene by peroxisome proliferator in primary human hepatocytes
-
expression in the presence of n-alkanes
expression is significantly induced by exogenous application of salicylic acid, methly jasmonate, 1-aminocyclopropane-l-carboxylic acid, and abscisic acid and exposure to NaCl and drought
expression of AlkB1 is induced by C12-C16 alkanes, expression of AlkB2 by C12-C24 alkanes
expression of prm gene clusters in is induced by gaseous n-alkanes (C2-C4) except methane
Q08KD8; Q08KD7 and Q08KD6; Q08KD5, Q08KE2; Q08KE1 and Q08KE0; Q08KD9
expression of prm gene clusters in Mycobacterium sp. TY-6 is induced by gaseous n-alkanes (C2–C4) except methane
Q08KD8; Q08KD7 and Q08KD6; Q08KD5, Q08KE2; Q08KE1 and Q08KE0; Q08KD9
expression of prm gene clusters in Pseudonocardia sp. TY-7 is induced by gaseous n-alkanes (C2-C4) except methane
Q08KD8; Q08KD7 and Q08KD6; Q08KD5, Q08KE2; Q08KE1 and Q08KE0; Q08KD9
genes alkB1, alkB2, p450 and almA are induced by alkanes ranging from C8 to C36, overview. Thereby the expression of the p450 and almA genes is only upregulated in the presence of medium-chain (C8-C16) or long-chain (C22-C36) n-alkanes, respectively, while alkB1 and alkB2 respond to both medium- and long-chain n-alkanes (C12-C26). Branched alkanes, like pristane and phytane, significantly elevate alkB1 and almA expression levels
in humans, the CYP4A11 gene is not induced by peroxisome proliferators
-
in the female labial palps, expression is weaker and restricted to a smaller area when compared to males
-
induction of alkW1 by n-alkanes ranging in length from 6 to 40 carbon atoms as sole carbon sources
induction of CYP4A genes by starvation (60-700fold), by peroxisome proliferators (30-70fold), ethanol, high fat diet (2.5-100fold), and in diabetes and steatohepatitis. Dramatic induction of both the mouse CYP4A10 and CYP4A14 genes in CYP2E1 knockout mice, which accounts for the increased reactive oxygen species that induce lipid peroxidation
-
no decrease in AlkB expression in presence of citrate
no induction of alkW2 by n-alkanes ranging in length from 6 to 40 carbon atoms as sole carbon sources
not induced by decanol and decanoic acid
similar to sxe1 mRNA, expression of SXE1 protein in males oscillates in a diurnal fashion, with highest protein levels occurring around midnight
-
the CYP153 gene promoter is induced by n-alkanes comprised of 8 to 14 carbon atoms