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1.14.15.3: alkane 1-monooxygenase

This is an abbreviated version!
For detailed information about alkane 1-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.3

Reaction

Octane
+
reduced rubredoxin
+
O2
+ 2 H+ =
1-Octanol
+
oxidized rubredoxin
+
H2O

Synonyms

1-hydroxylase, alkane 1-hydrolase, alkane hydroxylase, alkane mono-oxygenase, alkane monooxygenase, alkane omega-hydroxylase, alkane-1-monooxygenase 1, alkane-1-monooxygenase 2, AlkB, AlkB1, AlkB2, AlkW1, AlkW2, AlmA, AlmA-like alkane hydroxylase, BMO, butane monooxygenase, CYP omega hydroxylase, CYP omega-hydroxylase, Cyp153, CYP153 homologue, CYP153A, CYP153D17, CYP4 P450, CYP450 4A omega-hydroxylase, CYP450 omega-hydroxylase, CYP4A, CYP4A10, CYP4A11, CYP4A14, CYP4AII, CYP4d21, CYP86A1, CYP86B1, CYP94A1, CYPA11 P450, CYPIVA1, CYPIVA11, CYPIVA2, CYPIVA3, CYPIVA5, CYPIVA6, CYPIVA7, cytochrome P-450 omega-hydroxylase, cytochrome P450 alkane hydroxylase, cytochrome P450 omega hydroxylase, cytochrome P450-dependent fatty acid omega-hydroxylase, diiron omega-hydroxylase, FA omega-hydroxylase, fatty acid omega-hydrolase, Fatty acid omega-hydroxylase, Gpo1, hexane hydroxylase, Lauric acid omega-hydroxylase, MAH1-1, MAH1-2, male-specific fatty acid omega-hydroxylase, medium-chain alkane hydroxylase, methane monooxygenase, More, omega hydroxylase, omega-hydrolase, omega-hydroxylase, P-450 HK omega, P450-HL-omega, P452, Prm1ABCD, Prm2ABCD, propane monooxygenase, Rieske-type alkane monooxygenase, sex-specific enzyme 1, SXE1, UAM-Ps1, very long chain fatty acid hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.3 alkane 1-monooxygenase

Cofactor

Cofactor on EC 1.14.15.3 - alkane 1-monooxygenase

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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ferredoxin
-
Rieske-type alkane monooxygenase with Rieske-type [2Fe-2S]2 center
-
heme
dodecane, capric acid, and lauric acid binding to CYP153D17 induces a 90% shift in the heme spin state from low-spin (Soret maximum at 420 nm) to high-spin (Soret maximum at 390 nm), whereas decane and myristic acid induces a 80% shift in the same heme spin state
NAD(P)+
-
-
NAD(P)H
NAD+
-
very little activity at 1 mM level
rubredoxin
-