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1.14.15.20: heme oxygenase (biliverdin-producing, ferredoxin)

This is an abbreviated version!
For detailed information about heme oxygenase (biliverdin-producing, ferredoxin), go to the full flat file.

Reaction

protoheme
+ 6 reduced ferredoxin [iron-sulfur] cluster + 3 O2 + 6 H+ =
Biliverdin
+
Fe2+
+
CO
+ 6 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O

Synonyms

ferredoxin-dependent heme oxygenase, ferredoxin-dependent soluble heme oxygenase, haem oxygenase, heme oxygenase, HO-1, HO-2, Ho1, Ho2, Ho3, HO4, HY1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.20 heme oxygenase (biliverdin-producing, ferredoxin)

Activating Compound

Activating Compound on EC 1.14.15.20 - heme oxygenase (biliverdin-producing, ferredoxin)

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4,5-dihydroxy-1,3-benzene disulfonic acid
-
-
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
-
significantly increases enzyme activity
D-ascorbate
-
99% activity with D-ascorbate as compared to L-ascorbate
dehydroascorbate
-
-
desferrioxamine
HClO4
-
134% activity at 5% (v/v) HClO4
isoascorbate
-
-
L-ascorbate
o-phenanthroline
-
-
Tiron
-
almost as effective as desferrioxamine
additional information
-
not activated by EDTA, dehydroascorbate, and phenyledediamine
-