1.14.15.20: heme oxygenase (biliverdin-producing, ferredoxin)
This is an abbreviated version!
For detailed information about heme oxygenase (biliverdin-producing, ferredoxin), go to the full flat file.
Reaction
+ 6 reduced ferredoxin [iron-sulfur] cluster + 3 O2 + 6 H+ = + + + 6 oxidized ferredoxin [iron-sulfur] cluster + 3 H2O
Synonyms
ferredoxin-dependent heme oxygenase, ferredoxin-dependent soluble heme oxygenase, haem oxygenase, heme oxygenase, HO-1, HO-2, Ho1, Ho2, Ho3, HO4, HY1
ECTree
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Activating Compound
Activating Compound on EC 1.14.15.20 - heme oxygenase (biliverdin-producing, ferredoxin)
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6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
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significantly increases enzyme activity
additional information
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not activated by EDTA, dehydroascorbate, and phenyledediamine
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desferrioxamine
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6fold increase of activity in the presence of 2.5 mM desferrioxamine
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adding of a second electron donor, such as ascorbate, led to a 10fold increase in the heme conversion rate
L-ascorbate
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the enzyme requires an iron chelator and second reductant, such as L-ascorbate, for full activity