1.14.15.19: C-19 steroid 1alpha-hydroxylase
This is an abbreviated version!
For detailed information about C-19 steroid 1alpha-hydroxylase, go to the full flat file.
Word Map on EC 1.14.15.19
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1.14.15.19
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sorangium
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cellulosum
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myxobacterium
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regioselective
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biocatalyst
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adrenodoxin
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asparagine
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11-deoxycorticosterone
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androstenedione
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pharmacology
- 1.14.15.19
-
sorangium
- cellulosum
-
myxobacterium
-
regioselective
-
biocatalyst
- adrenodoxin
- asparagine
- 11-deoxycorticosterone
- androstenedione
- pharmacology
Reaction
+ 2 reduced ferredoxin [iron-sulfur] cluster + + 2 H+ = + + 2 oxidized ferredoxin [iron-sulfur] cluster
Synonyms
C-19 steroid 1alpha-hydroxylase, CYP260A1
ECTree
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Systematic Name
Systematic Name on EC 1.14.15.19 - C-19 steroid 1alpha-hydroxylase
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testosterone,reduced-ferredoxin:oxygen oxidoreductase (1alpha-hydroxylating)
The enzyme, characterized from the bacterium Sorangium cellulosum, is a class I cytochrome P-450, and uses ferredoxin as its electron donor [1]. It was shown to act on several C-19 steroid substrates, including testosterone, androstenedione, testosterone-acetate and 11-oxoandrostenedione [2].