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1.14.15.18: calcidiol 1-monooxygenase

This is an abbreviated version!
For detailed information about calcidiol 1-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.18

Reaction

calcidiol
+ 2 reduced adrenodoxin + 2 H+ +
O2
=
calcitriol
 + 2 oxidized adrenodoxin +
H2O

Synonyms

1-hydroxylase-25-hydroxyvitamin D3, 1-OHase, 1alpha,25-dihydroxyvitamin D hydroxylase, 1alpha-hydroxylase, 1alpha-OHase, 1alphaOHase, 25 hydroxy-vitamin D3-1alpha hydroxylase, 25(OH)VD3 1alpha-hydroxylase, 25-hydroxy D3-1alpha-hydroxylase, 25-hydroxycholecalciferol 1-hydroxylase, 25-hydroxycholecalciferol 1-monooxygenase, 25-hydroxycholecalciferol 1alpha-hydroxylase, 25-hydroxycholecalciferol-1-hydroxylase, 25-hydroxyvitamin D 1alpha-hydroxylase, 25-hydroxyvitamin D-1 alpha-hydroxylase, 25-hydroxyvitamin D-1-alpha-hydroxylase, 25-hydroxyvitamin D-1alpha-hydroxylase, 25-hydroxyvitamin D3 1alpha-hydroxylase, 25-hydroxyvitamin D3-1alpha-hydroxylase, 25-hydroxyvitamin-D3-1alpha-hydroxylase, CYB27B1, CYP1alpha, CYP27A, CYP27B1, cytochrome P450 25-hydroxyvitamin D3-1alpha-hydroxylase, EC 1.14.13.13, extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase, extra-renal 25-hydroxyvitamin D3 1alpha-hydroxylase, hydroxylase, 25-hydroxcholecalciferol 1-, More, oxygenase, 25-hydroxycholecalciferol 1-mono-, P450 cytochrome 25-hydroxyvitamin D3 1alpha-hydroxylase, VD3 25-hydroxylase, VDH, vitamin D 1alpha-hydroxylase, vitamin D hydroxylase, vitamin D3 25- and 1alpha-hydroxylase, vitamin D3 25-hydroxylase, vitamin D3 hydroxylase, [25(OH)D3]-1alpha-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.18 calcidiol 1-monooxygenase

Specific Activity

Specific Activity on EC 1.14.15.18 - calcidiol 1-monooxygenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000001
-
female human kidney
0.0000002
0.00000042
-
substrate 24-oxo-25-hydroxycholecalciferol, recombinant reconstituted system
0.00000058
-
substrate 25-hydroxycholecalciferol, recombinant reconstituted system
0.0000011
-
substrate 24-oxo-25-hydroxycholecalciferol
0.0000015
0.0000031
-
-
0.0000043
-
substrate 24,25-dihydroxycholecalciferol
0.0000048
-
with malate as electron source
0.0000072
-
purified cytochrome P-450 component of 1alpha-hydroxylase, reconstituted system
0.0000082
-
purified cytochrome P-450 component of 1alpha-hydroxylase, reconstituted system
0.00125
-
-
0.0048
-
purified enzyme
0.602
-
reduction of cytochrome P-450 at non-saturating level of enzyme components
0.687
-
ferredoxin activity, reduction of cytochrome c
11.38
-
reconstituted system of cytochrome P-450, cytochrome b5, adrenocortical ferredoxin reductase, and renal ferredoxin
6.758
-
purified ferredoxin, reduction of cytochrome c
additional information