1.14.15.16: vitamin D3 24-hydroxylase

This is an abbreviated version!
For detailed information about vitamin D3 24-hydroxylase, go to the full flat file.

Word Map on EC 1.14.15.16

1.14.15.16

cyp24a1

parathyroid

1alpha-hydroxylase

rickets

24,25-dihydroxyvitamin

hypercalcemia

24-hydroxylation

retinoids

d-dependent

1alpha,25oh2d3

osteocalcin

vdres

d-deficient

1-hydroxylase

d-responsive

1,25-dihydroxycholecalciferol

hyperparathyroidism

ketoconazole

nephrocalcinosis

alopecia

vdr-mediated

hypophosphatemic

d-binding

1,25oh2d3-induced

extrarenal

hypercalciuria

cholecalciferol

25-hydroxycholecalciferol

calcemic

1alpha-ohase

alpha-hydroxyvitamin

calcidiol

d-resistant

d3-1alpha-hydroxylase

osteomalacia

d-replete

secosteroid

hvdrr

sodium-phosphate

medicine

Reaction

+ 2 reduced adrenodoxin + 2 H+ +

+ 2 oxidized adrenodoxin +

Synonyms

1,25-(OH)2D3-24-hydroxylase, 1,25-dihydroxyvitamin D3 24-hydroxylase, 1alpha,25-dihydroxyvitamin D3 24-hydroxylase, 24-hydroxylase, 24-OHase, 24OHase, 25-hydroxyvitamin D-24-hydroxylase, 25-hydroxyvitamin D3-24-hydroxylase, 25-OH-D3-24-hydroxylase, CYP24A1, cytochrome P450 24A1, EC 1.14.13.126, P450cc24, vitamin D 24-hydroxylase, vitamin D-24-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.15.16 vitamin D3 24-hydroxylase

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Results	in table
4	Activating Compound
6	AA Sequence
1	Application
14	Cloned(Commentary)
41	Cofactor
463	Disease/ Diagnostics
9	Expression
14	General Information
16	IC50 Value
44	Inhibitors
13	kcat/KM [mM/s]
24	Ki Value [mM]
21	KM Value [mM]
10	Localization
1	Metals/Ions
6	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
32	Organism
2	Pathway
2	pH Optimum
28	Protein Variants
5	Purification (Commentary)
2	Reaction
2	Reaction Type
32	Reference
36	Source Tissue
105	Substrates and Products (Substrate)
2	Subunits
57	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
13	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.15.16 - vitamin D3 24-hydroxylase

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calcitriol,adrenodoxin:oxygen oxidoreductase (24-hydroxylating)

This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D3-26,23-lactone as end product while the mouse and rat enzymes do not. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase.