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1.14.15.16: vitamin D3 24-hydroxylase

This is an abbreviated version!
For detailed information about vitamin D3 24-hydroxylase, go to the full flat file.

Word Map on EC 1.14.15.16

Reaction

calcidiol
+ 2 reduced adrenodoxin + 2 H+ +
O2
=
secalciferol
+ 2 oxidized adrenodoxin +
H2O

Synonyms

1,25-(OH)2D3-24-hydroxylase, 1,25-dihydroxyvitamin D3 24-hydroxylase, 1alpha,25-dihydroxyvitamin D3 24-hydroxylase, 24-hydroxylase, 24-OHase, 24OHase, 25-hydroxyvitamin D-24-hydroxylase, 25-hydroxyvitamin D3-24-hydroxylase, 25-OH-D3-24-hydroxylase, CYP24A1, cytochrome P450 24A1, EC 1.14.13.126, P450cc24, vitamin D 24-hydroxylase, vitamin D-24-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.16 vitamin D3 24-hydroxylase

Substrates Products

Substrates Products on EC 1.14.15.16 - vitamin D3 24-hydroxylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1alpha,23,25-trihydroxyvitamin D3 + NADPH + H+ + O2
1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O
show the reaction diagram
1alpha,24(R)-dihydroxyvitamin D3 + NADPH + H+ + O2
?
show the reaction diagram
1alpha,24R,25-trihydroxyvitamin D3 + NADPH + O2
calcitroic acid + NADP+ + ?
show the reaction diagram
1alpha,25-dihydroxy-3-epi-vitamin D3 + NADPH + H+ + O2
?
show the reaction diagram
-
-
-
-
?
1alpha,25-dihydroxy-3-epivitamin-D3 + NADPH + H+ + O2
?
show the reaction diagram
-
-
-
-
?
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
1alpha,23,25-trihydroxyvitamin D3 + 25,26,27-trinor-23-ene-1alpha-hydroxyvitamin D3 + NADP+ + H2O
show the reaction diagram
-
after hydrogen abstraction of the C-23 position of 1alpha,25-dihydroxyvitamin D3, part of the substrate-radical intermediate is converted into 25,26,27-trinor-23-ene-1alpha-hydroxyvitamin D3, while a major part of them is converted into 1alpha,23,25-trihydroxyvitamin D3
-
-
?
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
1alpha,23,25-trihydroxyvitamin D3 + NADP+ + H2O
show the reaction diagram
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
1alpha,23S,25,26-tetrahydroxyvitamin D3 + 1alpha,23S,25-trihydroxyvitamin D3 + 25,26,27-trinor-23-ene-1alpha-hydroxyvitamin D3 + NADP+ + H2O
show the reaction diagram
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
1alpha,24(R)-dihydroxyvitamin D3 + NADP+ + H2O
show the reaction diagram
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
1alpha,24,25-trihydroxyvitamin D3 + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O
show the reaction diagram
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O
show the reaction diagram
-
C23-hydroxylation
-
-
?
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
24-oxo-1,23,25-trihydroxyvitamin D3 + 24,25,26,27-tetranor-1,23-dihydroxyvitamin D3 + 1alpha,24R,25-trihydroxyvitamin D3 + 24-oxo-1,25-dihydroxyvitamin D3 + NADP+ + H2O
show the reaction diagram
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
calcitroic acid + NADP+ + ?
show the reaction diagram
1alpha-hydroxyvitamin D2 + NADPH + H+ + O2
1alpha,24-dihydroxyvitamin D2 + 1alpha,25-dihydroxyvitamin D2 + 26-carboxy-1alpha,24-dihydroxyvitamin D2 + NADP+ + H2O
show the reaction diagram
1beta,25-dihydroxy-3-epi-vitamin D3 + NADPH + H+ + O2
?
show the reaction diagram
-
-
-
-
?
1beta,25-dihydroxy-3-epivitamin-D3 + NADPH + H+ + O2
?
show the reaction diagram
-
-
-
-
?
1beta,25-dihydroxyvitamin D3 + NADPH + H+ + O2
? + NADP+ + H2O
show the reaction diagram
2-methylene-19-nor-(20R)-1,25-dihydroxyvitamin D3 + NADPH + H+ + O2
? + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 + NADPH + H+ + O2
? + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
23-oxo-24,25,26,27-tetranor-1alpha-hydroxyvitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
calcitroic acid + 2 oxidized adrenodoxin + H2O
show the reaction diagram
24,25,26,27-tetranor-1alpha,23-dihydroxyvitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
23-oxo-24,25,26,27-tetranor-1alpha-hydroxyvitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
24-oxo-1alpha,23,25-trihydroxyvitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
24,25,26,27-tetranor-1alpha,23-dihydroxyvitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
24-oxo-1alpha,25-dihydroxyvitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
24-oxo-1alpha,23,25-trihydroxyvitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
25-hydroxyvitamin D3 + NADPH + H+ + O2
1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O
show the reaction diagram
25-hydroxyvitamin D3 + NADPH + H+ + O2
24,25,26,27-tetranor-23-hydroxyvitamin-D3 + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
25-hydroxyvitamin D3 + NADPH + H+ + O2
24,25-dihydroxyvitamin D3 + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
25-hydroxyvitamin D3 + NADPH + H+ + O2
24-oxo-25-hydroxyvitamin D3 + 23(S),25-dihydroxyvitamin D3 + 24(R),25-dihydroxyvitamin D3 + 24-oxo-23(S),25-dihydoxyvitamin D3 + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
25-hydroxyvitamin D3 + NADPH + H+ + O2
24R,25-dihydroxyvitamin D3 + NADP+ + H2O
show the reaction diagram
25-hydroxyvitamin D3 + NADPH + H+ + O2
25,26,27-trinor-23-ene-vitamin D3 + NADP+ + H2O
show the reaction diagram
-
-
the metabolite 25,26,27-trinor-23-ene-vitamin D3 is closely related with the C-23 hydroxylation pathway
-
?
25-hydroxyvitamin D3 + NADPH + H+ + O2
secalciferol + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
3-epi-1alpha,23,25-trihydroxy-24-oxo-vitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
3-epi-1alpha,23-dihydroxy-24,25,26,27-tetranor-vitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
3-epi-1alpha,23,25-trihydroxyvitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
3-epi-1alpha,23,26-trihydroxyvitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
3-epi-1alpha,23,25-trihydroxyvitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
3-epi-1alpha,25-dihydroxy-23-oxovitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
3-epi-1alpha,23-dihydroxy-24,25,26,27-tetranor-vitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
3-epicalcitroic acid + 2 oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
3-epi-1alpha,24,25-trihydroxyvitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
3-epi-1alpha,25-dihydroxy-24-oxo-vitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
3-epi-1alpha,25-dihydroxy-24-oxo-vitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
3-epi-1alpha,23,25-trihydroxy-24-oxo-vitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
3-epi-1alpha,25-dihydroxyvitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
3-epi-1alpha,23,25-trihydroxyvitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
3-epi-1alpha,25-dihydroxyvitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
3-epi-1alpha,24,25-trihydroxyvitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
3-epi-1alpha,25-dihydroxyvitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
3-epi-25,26,27-trinor-23-ene-1alpha-hydroxyvitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
3-epi-25,26,27-trinor-23-ene-1alpha-hydroxyvitamin D3 + 2 reduced adrenodoxin + 2 H+ + O2
3-epi-25,26,27-trinor-23,24-epoxide-1alpha-hydroxyvitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2
secalciferol + 2 oxidized adrenodoxin + H2O
show the reaction diagram
calcidiol + NADPH + H+ + O2
secalciferol + NADP+ + H2O
show the reaction diagram
calcitetrol + 2 reduced adrenodoxin + 2 H+ + O2
24-oxo-1alpha,25-dihydroxyvitamin D3 + 2 oxidized adrenodoxin + H2O
show the reaction diagram
calcitriol + 2 reduced adrenodoxin + 2 H+ + O2
calcitetrol + 2 oxidized adrenodoxin + H2O
show the reaction diagram
calcitriol + NADPH + H+ + O2
calcitetrol + NADP+ + H2O
show the reaction diagram
additional information
?
-