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1.14.15.16: vitamin D3 24-hydroxylase

This is an abbreviated version!
For detailed information about vitamin D3 24-hydroxylase, go to the full flat file.

Word Map on EC 1.14.15.16

Reaction

calcidiol
+ 2 reduced adrenodoxin + 2 H+ +
O2
=
secalciferol
 + 2 oxidized adrenodoxin +
H2O

Synonyms

1,25-(OH)2D3-24-hydroxylase, 1,25-dihydroxyvitamin D3 24-hydroxylase, 1alpha,25-dihydroxyvitamin D3 24-hydroxylase, 24-hydroxylase, 24-OHase, 24OHase, 25-hydroxyvitamin D-24-hydroxylase, 25-hydroxyvitamin D3-24-hydroxylase, 25-OH-D3-24-hydroxylase, CYP24A1, cytochrome P450 24A1, EC 1.14.13.126, P450cc24, vitamin D 24-hydroxylase, vitamin D-24-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.16 vitamin D3 24-hydroxylase

KI Value

KI Value on EC 1.14.15.16 - vitamin D3 24-hydroxylase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00054
(E)-3-(4-styryl-1H-indol-1-yl)propyl benzenesulfinate
pH 7.5, 37°C
0.000031
1-[3-(1H-imidazol-1-yl)propyl]-4-(3,5-dimethoxystyryl)-1H-indole
pH 7.5, 37°C
0.000026
1-[3-(1H-imidazol-1-yl)propyl]-4-styryl-1H-indole
pH 7.5, 37°C
0.000037
1-[3-(1H-imidazol-1-yl)propyl]-5-styryl-1H-indole
pH 7.5, 37°C
0.000014
1-[4-(1H-imidazol-1-yl)butyl]-4-(3,5-dimethoxystyryl)-1H-indole
pH 7.5, 37°C
0.000014
1-[4-(1H-imidazol-1-yl)butyl]-4-styryl-1H-indole
pH 7.5, 37°C
0.000037
1-[4-(1H-imidazol-1-yl)butyl]-5-styryl-1H-indole
pH 7.5, 37°C
0.00034
4-methyl-N-[3-(4-styryl-indol-1-yl)propyl]benzenesulfonamide
pH 7.5, 37°C
0.00023
4-methyl-N-[4-(4-styryl-indol-1-yl)butyl]benzenesulfonamide
pH 7.5, 37°C
1.05
5-cyclohexylpentyl beta-D-maltoside
-
pH and temperature not specified in the publication
1.88
6-cyclohexylhexyl beta-D-maltoside
-
pH and temperature not specified in the publication
0.95
7-cyclohexylheptyl beta-D-maltoside
-
pH and temperature not specified in the publication
3.65
CHAPS
-
pH and temperature not specified in the publication
0.37
Facade-EM
-
pH and temperature not specified in the publication
1.67
Fos-choline-14
-
pH and temperature not specified in the publication
0.000035
ketoconazole
pH 7.5, 37°C
0.00073
N-(3-(4-[2-(3,5-dimethoxy-phenyl)-vinyl]-indol-1yl)-propyl)-4-methyl-benzenesulfonamide
pH 7.5, 37°C
0.00074
N-(4-(4-[2-(3,5-dimethoxy-phenyl)-vinyl]-indol-1yl)-butyl)-4-methyl-benzenesulfonamide
pH 7.5, 37°C
0.29 - 6.9
n-dodecyl beta-D-maltoside
0.29
octa ethylene glycol monododecyl ether
-
pH and temperature not specified in the publication
0.00064
toluene-4-sulfonic acid 3-(4-styryl-indol-1-yl)-propyl ester
pH 7.5, 37°C
0.00119
toluene-4-sulfonic acid 3-(4-[2-(3,5-dimethoxy-phenyl)-vinyl]-indol-1-yl)-propyl ester
pH 7.5, 37°C
0.000039
vitamin D sulfonate
pH 7.5, 37°C