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1.14.15.16: vitamin D3 24-hydroxylase

This is an abbreviated version!
For detailed information about vitamin D3 24-hydroxylase, go to the full flat file.

Word Map on EC 1.14.15.16

Reaction

calcidiol
+ 2 reduced adrenodoxin + 2 H+ +
O2
=
secalciferol
 + 2 oxidized adrenodoxin +
H2O

Synonyms

1,25-(OH)2D3-24-hydroxylase, 1,25-dihydroxyvitamin D3 24-hydroxylase, 1alpha,25-dihydroxyvitamin D3 24-hydroxylase, 24-hydroxylase, 24-OHase, 24OHase, 25-hydroxyvitamin D-24-hydroxylase, 25-hydroxyvitamin D3-24-hydroxylase, 25-OH-D3-24-hydroxylase, CYP24A1, cytochrome P450 24A1, EC 1.14.13.126, P450cc24, vitamin D 24-hydroxylase, vitamin D-24-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.16 vitamin D3 24-hydroxylase

Inhibitors

Inhibitors on EC 1.14.15.16 - vitamin D3 24-hydroxylase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,3S,5Z,7E,14x)-17-[(2R)-1-(1H-imidazol-1-yl)propan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol
-
potent and selective CYP24A1 inhibitor
(1R,3S,5Z,7E,14x)-17-[(2S)-7-cyclopropylheptan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol
-
potent and selective CYP24A1 inhibitor
(2R)-2-[(4E,7aR)-4-[(2Z)-2-[(5R)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyloctahydro-1H-inden-1-yl]propyl bromoacetate
-
-
(3R,5Z,7E,14x,17x,20S)-3-hydroxy-9,10-secochola-5,7,10-trien-24-yl 4-methylbenzenesulfonate
-
-
(E)-3-(4-styryl-1H-indol-1-yl)propyl benzenesulfinate
-
1-[3-(1H-imidazol-1-yl)propyl]-4-(3,5-dimethoxystyryl)-1H-indole
-
1-[3-(1H-imidazol-1-yl)propyl]-4-styryl-1H-indole
-
1-[3-(1H-imidazol-1-yl)propyl]-5-styryl-1H-indole
-
1-[4-(1H-imidazol-1-yl)butyl]-4-(3,5-dimethoxystyryl)-1H-indole
-
1-[4-(1H-imidazol-1-yl)butyl]-4-styryl-1H-indole
-
1-[4-(1H-imidazol-1-yl)butyl]-5-styryl-1H-indole
-
2-(4-hydroxybenzyl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one
-
-
24-carboxyl-25-hydroxyvitamin D3
-
-
24-difluoro-1,25-dihydroxyvitamin D3
-
-
4-methyl-N-[3-(4-styryl-indol-1-yl)propyl]benzenesulfonamide
-
4-methyl-N-[4-(4-styryl-indol-1-yl)butyl]benzenesulfonamide
-
5-cyclohexylpentyl beta-D-maltoside
-
-
6-cyclohexylhexyl beta-D-maltoside
-
-
7-cyclohexylheptyl beta-D-maltoside
-
-
CHAPS
-
inhibits ligand binding to the CYP24A1:adrenodoxin complex at concentrations well below their reported critical micelle concentration (CMC) values
CTA018
-
-
CTA091
-
-
Facade-EM
-
-
Fos-choline-14
-
-
ketoconazole
liarozole
Metyrapone
-
complete inhibition at 5 mM
N-(3-(4-[2-(3,5-dimethoxy-phenyl)-vinyl]-indol-1yl)-propyl)-4-methyl-benzenesulfonamide
-
N-(4-(4-[2-(3,5-dimethoxy-phenyl)-vinyl]-indol-1yl)-butyl)-4-methyl-benzenesulfonamide
-
n-dodecyl beta-D-maltoside
-
-
N-[2-(1H-imidazol-1-yl)-2-phenylethyl]-4-[(E)-2-phenylethenyl]benzamide
-
nonyl-beta-D-glucoside
-
-
octa ethylene glycol monododecyl ether
-
-
SKF 525 A
-
75% inhibition at 0.3 mM
toluene-4-sulfonic acid 3-(4-styryl-indol-1-yl)-propyl ester
-
toluene-4-sulfonic acid 3-(4-[2-(3,5-dimethoxy-phenyl)-vinyl]-indol-1-yl)-propyl ester
-
VID400
-
i.e. (R)-N-(2-(1H-imidazol-1-yl)-2-phenylethyl)-4-chlorobiphenyl-4-carboxamide, exhibits strong and selective CYP24A1 inhibitory activity
vitamin D sulfonate
-
additional information
-