1.14.15.15: cholestanetriol 26-monooxygenase

This is an abbreviated version!
For detailed information about cholestanetriol 26-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.15

Reaction

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al
+ 2 reduced adrenodoxin + 2 H+ +
O2
=
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate
+ 2 oxidized adrenodoxin +
H2O

Synonyms

5beta-cholestane-3 alpha,7alpha,12alpha,26-tetrol dehydrogenase, 5beta-cholestane-3 alpha,7alpha,12alpha-triol-26-al oxidoreductase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 27-monooxygenase, 5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase, cholestanetriol 26-hydroxylase, cholestanetriol 27-hydroxylase, cholesterol C-26 hydroxylase, cholesterol hydroxylase, CYP125A4, CYP27, CYP27A, CYP27A1, cytochrome P-450 sterol 26-hydroxylase, cytochrome P-450A, cytochrome P450 125A4, cytochrome P450 27A, cytochrome P450c27, dehydrogenase, cholestanetetrol 26-, hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol, More, oxygenase, cholestanetriol 26-mono-, P450 27A1, sterol 27-hydroxylase, TEHC-NAD oxidoreductase, vitamin D3 25-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.15 cholestanetriol 26-monooxygenase

Substrates Products

Substrates Products on EC 1.14.15.15 - cholestanetriol 26-monooxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(24S)-3beta-hydroxy-24-methyl-5alpha-cholesta-8(14),22-dien-15-one + reduced adrenodoxin + H+ + O2
?
show the reaction diagram
(25R)-5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol + reduced adrenodoxin + O2
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
-
?
1alpha-hydroxyvitamin D3 + reduced adrenodoxin + O2
1alpha,25-dihydroxyvitamin D3 + oxidized adrenodoxin + H2O
show the reaction diagram
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + reduced adrenodoxin + O2
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
-
?
3beta-hydroxy-5alpha-cholest-8(14)-en-15-one + reduced adrenodoxin + H+ + O2
?
show the reaction diagram
5-cholestene-3beta,7alpha-diol + reduced adrenodoxin + O2
5-cholestene-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
-
?
5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + reduced adrenodoxin + O2
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + oxidized adrenodoxin + H2O
show the reaction diagram
5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol + reduced adrenodoxin + O2
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane-27-oic acid + oxidized adrenodoxin + H2O
show the reaction diagram
-
oxidation to the corresponding C27-acid
-
-
?
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + H+ + O2
(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
-
?
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2
(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O
show the reaction diagram
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2
(25R)-5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
-
?
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid + oxidzed adrenodoxin + H2O
show the reaction diagram
-
-
-
-
?
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2
5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
-
?
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2
5beta-cholestane-3alpha,7alpha,12alpha,27-tetrol + oxidized adrenodoxin + H2O
show the reaction diagram
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2
?
show the reaction diagram
5beta-cholestane-3alpha,7alpha-diol + reduced adrenodoxin + O2
5beta-cholestane-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
-
?
5beta-cholestane-3alpha,7alpha-diol + reduced adrenodoxin + O2
?
show the reaction diagram
-
-
-
-
?
5beta-cholestane-3alpha-ol + reduced adrenodoxin + O2
?
show the reaction diagram
-
-
-
-
?
7-dehydrocholesterol + 4 reduced adrenodoxin + 2 H+ + 2 O2
25-hydroxy-7-dehydrocholesterol + 26/27-hydroxy-7-dehydrocholesterol + 4 oxidzed adrenodoxin + 2 H2O
show the reaction diagram
-
-
metabolites detected in serum of a patient with Smith-Lemli-Opitz syndrome. 25-hydroxy-7-dehydrocholesterol activates liver X receptors LXRalpha, LXRbeta and vitamin D receptor and 26/27-hydroxy-7-dehydrocholesterol induces activation of LXRalpha and LXRbeta, although the activities of both compounds on LXRs are weak. 26/27-Hydroxy-7-dehydrocholesterol is (3S,25S)-cholesta-5,7-diene-3,26-diol or (3S,25R)-cholesta-5,7-diene-3,26-diol
-
?
7alpha-hydroxy-4-cholesten-3-one + reduced adrenodoxin + O2
7alpha,26-dihydroxy-4-cholesten-3-one + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
-
?
beta-sitosterol + reduced adrenodoxin + O2
26-hydroxy-beta-sitosterol + 29-hydroxy-beta-sitosterol + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
cholesterol + reduced adrenodoxin + H+ + O2
26-hydroxycholesterol + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
-
?
cholesterol + reduced adrenodoxin + O2
24-hydroxycholesterol + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
-
?
cholesterol + reduced adrenodoxin + O2
25-hydroxycholesterol + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
-
?
cholesterol + reduced adrenodoxin + O2
26-hydroxycholesterol + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
cholesterol + reduced adrenodoxin + O2
27-hydroxycholesterol + oxidized adrenodoxin + H2O
show the reaction diagram
cholesterol + reduced adrenodoxin + O2
?
show the reaction diagram
-
-
-
-
?
ergosterol + reduced adrenodoxin + O2
24-hydroxyergosterol + 26-hydroxyergosterol + 28-hydroxyergosterol + oxidized adrenodoxin + H2O
show the reaction diagram
-
-
-
?
additional information
?
-