1.14.15.15: cholestanetriol 26-monooxygenase

This is an abbreviated version!
For detailed information about cholestanetriol 26-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.15

Reaction

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al
+ 2 reduced adrenodoxin + 2 H+ +
O2
=
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate
+ 2 oxidized adrenodoxin +
H2O

Synonyms

5beta-cholestane-3 alpha,7alpha,12alpha,26-tetrol dehydrogenase, 5beta-cholestane-3 alpha,7alpha,12alpha-triol-26-al oxidoreductase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 27-monooxygenase, 5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase, cholestanetriol 26-hydroxylase, cholestanetriol 27-hydroxylase, cholesterol C-26 hydroxylase, cholesterol hydroxylase, CYP125A4, CYP27, CYP27A, CYP27A1, cytochrome P-450 sterol 26-hydroxylase, cytochrome P-450A, cytochrome P450 125A4, cytochrome P450 27A, cytochrome P450c27, dehydrogenase, cholestanetetrol 26-, hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol, More, oxygenase, cholestanetriol 26-mono-, P450 27A1, sterol 27-hydroxylase, TEHC-NAD oxidoreductase, vitamin D3 25-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.15 cholestanetriol 26-monooxygenase

Cloned

Cloned on EC 1.14.15.15 - cholestanetriol 26-monooxygenase

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CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
CYP27 expression analysis in the brain
-
DNA and amino acid sequence determinationa nd analysis, functional expression in COS-M6 cells, overview
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expression analysis
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expression of wild-type and mutant enzymes in Escherichia coli
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gene CYP27A1, cloned from liver cDNA, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis
gene CYP27A1, DNA and amino acid sequence determination and analysis, genotyping, overview
gene CYP27A1, DNA and amino acid sequence determination and genomic analysis, genotyping
-
gene CYP27A1, quantitative real-time PCR enzyme expression analysis
gene CYP27A1, recombinant expression of His-tagged enzyme in Bacillus megaterium
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