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1.14.14.B11: nicotine demethylase

This is an abbreviated version!
For detailed information about nicotine demethylase, go to the full flat file.

Word Map on EC 1.14.14.B11

Reaction

(R)-nicotine
+
O2
 +
[reduced NADPH-hemoprotein reductase]
 +
O2
=
(R)-nornicotine
 +
formaldehyde
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

CYP82E, CYP82E1, CYP82E10, CYP82E2, CYP82E21, CYP82E3, CYP82E4, CYP82E4v1, CYP82E5v2, nicotine N-demethylase, NND

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.B11 nicotine demethylase

Inhibitors

Inhibitors on EC 1.14.14.B11 - nicotine demethylase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-aminobenzotriazole
at 1 mM inhibits by 17%
anti-CYP2A6 antibody
-
-
-
Chloropromazine
1 mM, 87% inhibition of recombinant nicotine demethylase activity in yeast microsomes
chlorpromazine
at 1 mM inhibits by 87%
CO
partial reverse activity after light exposure
coumarin
-
-
cytochrome c
1 mM, 78% inhibition of recombinant nicotine demethylase activity in yeast microsomes
oxidized cytochrome c
at 0.1 mM inhibits by 78%
-
Piperonylbutoxide
at 1 mM inhibits by 42%
additional information
-
not inhibitory: quinidine, anti-CYP2D6 serum, ketoconazole, anti-CYP3A4 serum
-