1.14.14.60: ferruginol monooxygenase

This is an abbreviated version!
For detailed information about ferruginol monooxygenase, go to the full flat file.

Reaction

Synonyms

Cyp76AH22, Cyp76AH23, CYP76AH24, CYP76AH3

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.60 ferruginol monooxygenase

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4	AA Sequence
1	Application
1	Cloned(Commentary)
3	Cofactor
1	Crystallization (Commentary)
1	General Information
5	Organism
3	Pathway
2	Protein Variants
1	Reaction
5	Reference
2	Source Tissue
6	Substrates and Products (Substrate)
11	Synonyms
1	Systematic Name

General Information

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General Information on EC 1.14.14.60 - ferruginol monooxygenase

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physiological function

Salvia miltiorrhiza

A0A0Y0GRS3

cytochrome CYP76AH3 oxidizes ferruginol at two different carbon centers, and CYP76AK1 hydroxylates at C-20 of two of the resulting intermediates. Together, they convert ferruginol into 11,20-dihydroxy ferruginol and 11,20-dihydroxy sugiol en route to tanshinones. Silencing of CYP76AH3 leads to significant reduction in concentration of 11-hydroxyferruginol and 11-hydroxysugiol

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