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1.14.14.56: 1,8-cineole 2-exo-monooxygenase

This is an abbreviated version!
For detailed information about 1,8-cineole 2-exo-monooxygenase, go to the full flat file.

Reaction

1,8-cineole
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
2-exo-hydroxy-1,8-cineole
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

CYP3A4, CYP3A5, EC 1.14.13.157

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.56 1,8-cineole 2-exo-monooxygenase

General Information

General Information on EC 1.14.14.56 - 1,8-cineole 2-exo-monooxygenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
CYP3A4 is a major enzyme involved in the oxidation of 1,8-cineole by human liver microsomes, as there is a good correlation between CYP3A4 contents and 1,8-cineole 2-hydroxylation activities in liver microsomes of eighteen human samples and of various recombinant human P450 enzymes examined, CYP3A4 has the highest activities for 1,8-cineole 2-hydroxylation