1.14.14.46: pimeloyl-[acyl-carrier protein] synthase

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For detailed information about pimeloyl-[acyl-carrier protein] synthase, go to the full flat file.

Reaction

Synonyms

CYP107H1, cytochrome P450BioI, EC 1.14.15.12, fatty acid hydroxylase, P450 BioI, P450BioI

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.46 pimeloyl-[acyl-carrier protein] synthase

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Results	in table
314	AA Sequence
5	Cloned(Commentary)
1	Crystallization (Commentary)
4	General Information
9	Inhibitors
4	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
108	Organism
2	Pathway
1	pI Value
3	Purification (Commentary)
10	Reaction
8	Reference
20	Substrates and Products (Substrate)
5	Subunits
18	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.14.46 - pimeloyl-[acyl-carrier protein] synthase

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SYSTEMATIC NAME

IUBMB Comments

acyl-[acyl-carrier protein],reduced-flavodoxin:oxygen oxidoreductase (pimeloyl-[acyl-carrier protein] forming)

A cytochrome P-450 (heme-thiolate) protein. The enzyme catalyses an oxidative C-C bond cleavage of long-chain acyl-[acyl-carrier protein]s of various lengths to generate pimeloyl-[acyl-carrier protein], an intermediate in the biosynthesis of biotin. The preferred substrate of the enzyme from the bacterium Bacillus subtilis is palmitoyl-[acyl-carrier protein] which then gives heptanal as the alkanal. The mechanism is similar to EC 1.14.15.6, cholesterol monooxygenase (side-chain-cleaving), followed by a hydroxylation step, which may occur spontaneously [2].