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1.14.14.46: pimeloyl-[acyl-carrier protein] synthase

This is an abbreviated version!
For detailed information about pimeloyl-[acyl-carrier protein] synthase, go to the full flat file.

Reaction

a (7R,8R)-7,8-dihydroxy-long-chain-acyl-[acyl-carrier protein]
+
reduced flavodoxin
+
O2
=
a 7-oxoheptanoyl-[acyl-carrier protein]
+
an n-alkanal
+
oxidized flavodoxin
+ 2 H2O

Synonyms

CYP107H1, cytochrome P450BioI, EC 1.14.15.12, fatty acid hydroxylase, P450 BioI, P450BioI

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.46 pimeloyl-[acyl-carrier protein] synthase

Reference

Reference on EC 1.14.14.46 - pimeloyl-[acyl-carrier protein] synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stok, J.E.; De Voss, J.
Expression, purification, and characterization of BioI: a carbon-carbon bond cleaving cytochrome P450 involved in biotin biosynthesis in Bacillus subtilis
Arch. Biochem. Biophys.
384
351-360
2000
Bacillus subtilis
Manually annotated by BRENDA team
Cryle, M.J.
Selectivity in a barren landscape: the P450BioI-ACP complex
Biochem. Soc. Trans.
38
934-939
2010
Bacillus subtilis
Manually annotated by BRENDA team
Lawson, R.J.; Leys, D.; Sutcliffe, M.J.; Kemp, C.A.; Cheesman, M.R.; Smith, S.J.; Clarkson, J.; Smith, W.E.; Haq, I.; Perkins, J.B.; Munro, A.W.
Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis
Biochemistry
43
12410-12426
2004
Bacillus subtilis
Manually annotated by BRENDA team
Cryle, M.J.; De Voss, J.J.
Carbon-carbon bond cleavage by cytochrome p450BioI (CYP107H1)
Chem. Commun. (Camb. )
10
86-87
2004
Bacillus subtilis
Manually annotated by BRENDA team
Roh, C.; Choi, K.; Pandey, B.; Kim, B.
Hydroxylation of daidzein by CYP107H1 from Bacillus subtilis 168
J. Mol. Catal. B
59
248-253
2009
Bacillus subtilis, Bacillus subtilis 168
-
Manually annotated by BRENDA team
Cryle, M.J.; Matovic, N.J.; De Voss, J.J.
Products of cytochrome P450BioI (CYP107H1)-catalyzed oxidation of fatty acids
Org. Lett.
5
3341-3344
2003
Bacillus subtilis
Manually annotated by BRENDA team
Cryle, M.J.; Schlichting, I.
Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450BioI ACP complex
Proc. Natl. Acad. Sci. USA
105
15696-15701
2008
Bacillus subtilis (P53554)
Manually annotated by BRENDA team