1.14.14.45: aromatic aldoxime N-monooxygenase

This is an abbreviated version!
For detailed information about aromatic aldoxime N-monooxygenase, go to the full flat file.

Reaction

S-[(E)-N-hydroxy(indol-3-yl)acetimidoyl]-L-glutathione

+ 2 H2O

Synonyms

At4g31500, CYP83B1, cytochrome P450 83B1, HM347235

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.45 aromatic aldoxime N-monooxygenase

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Results	in table
2	AA Sequence
5	Cloned(Commentary)
2	Cofactor
10	General Information
3	Inhibitors
3	kcat/KM [mM/s]
7	KM Value [mM]
8	Natural Substrates/ Products (Substrates)
12	Organism
4	Pathway
1	pH Optimum
6	Reaction
12	Reference
3	Source Tissue
22	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name
9	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.14.45 - aromatic aldoxime N-monooxygenase

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(E)-indol-3-ylacetaldoxime,[reduced NADPHhemoprotein reductase],glutathione:oxygen oxidoreductase (oxime-hydroxylating)

This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of glucosinolates in plants. The enzyme catalyses the N-hydroxylation of aromatic aldoximes derived from L-tryptophan, L-phenylalanine, and L-tyrosine, forming an aci-nitro intermediate that reacts non-enzymically with glutathione to produce an N-alkyl-thiohydroximate adduct, the committed precursor of glucosinolates. In the absence of glutathione, the enzyme is suicidal, probably due to interaction of the reactive aci-nitro compound with catalytic residues in the active site.