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1.14.14.36: tyrosine N-monooxygenase

This is an abbreviated version!
For detailed information about tyrosine N-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.36

Reaction

L-tyrosine
+ 2 O2 + 2 [reduced NADPH-hemoprotein reductase] =
(E)-[4-hydroxyphenylacetaldehyde oxime]
+ 2 [oxidized NADPH-hemoprotein reductase] +
CO2
+ 3 H2O

Synonyms

CYP79, CYP79A1, cytochrome P-450tyr, cytochrome P450 CYP79E1, cytochrome P450 CYP79E2, Cytochrome P450Tyr, EC 1.14.13.41, P450Tyr, tyrosine N-hydroxylase, Tyrosine N-monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.36 tyrosine N-monooxygenase

Engineering

Engineering on EC 1.14.14.36 - tyrosine N-monooxygenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
mutant 1: first codons of Escherichia coli mRNA are enriched for A's and T's, second codon is changed into GCT, first 8 codons of P450 sequence are replaced with the N-terminal sequence of bovine P45017alpha, mutant 2: deletion of 14 amino acids, mutant 3: deletion of 25 amino acids, mutant 4: deletion of 75 amino acids