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17-hydroxy-5alpha-pregnan-3alpha-ol-20-one + [reduced NADPH-hemoprotein reductase] + O2
androsterone + [oxidized NADPH-hemoprotein reductase] + H2O
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17alpha-hydroxy-5alpha-dihydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2
5alpha-androstanedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
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?
17alpha-Hydroxypregnenolone
Dehydroepiandrosterone + acetaldehyde
17alpha-hydroxypregnenolone + AH2 + O2
dehydroepiandrosterone + acetate + A + H2O
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
5alpha-dihydroprogesterone + [reduced NADPH-hemoprotein reductase] + O2
17alpha-hydroxy-5alpha-dihydroprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
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?
5alpha-pregnan-3alpha-ol-20-one + [reduced NADPH-hemoprotein reductase] + O2
17-hydroxy-5alpha-pregnan-3alpha-ol-20-one + [oxidized NADPH-hemoprotein reductase] + H2O
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?
7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2
7-dehydro-dehydroepiandrosterone + acetate + A + H2O
7-dehydro-pregnenolone + AH2 + O2
7-dehydro-17alpha-hydroxy-pregnenolone + A + H2O
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?
7-dehydro-pregnenolone + AH2 + O2
7-dehydro-17alpha-hydroxypregnenolone + A + H2O
7alpha-hydroxypregnenolone + [reduced NADPH-hemoprotein reductase] + O2
3beta-hydroxyandrost-5-en-17-one + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
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17,20-lyase activity
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?
pregnenolone + reduced acceptor + O2
17alpha-hydroxypregnenolone + oxidized acceptor + H2O
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i.e. pregn-5-en-3beta-ol-20-one
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?
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2
17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
progesterone + [reduced NADPH-hemoprotein reductase] + O2
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
additional information
?
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17alpha-Hydroxypregnenolone
Dehydroepiandrosterone + acetaldehyde
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17,20-lyase activity
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?
17alpha-Hydroxypregnenolone
Dehydroepiandrosterone + acetaldehyde
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17,20-lyase activity
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?
17alpha-hydroxypregnenolone + AH2 + O2
dehydroepiandrosterone + acetate + A + H2O
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?
17alpha-hydroxypregnenolone + AH2 + O2
dehydroepiandrosterone + acetate + A + H2O
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?
17alpha-hydroxypregnenolone + AH2 + O2
dehydroepiandrosterone + acetate + A + H2O
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?
17alpha-hydroxypregnenolone + AH2 + O2
dehydroepiandrosterone + acetate + A + H2O
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?
17alpha-hydroxypregnenolone + AH2 + O2
dehydroepiandrosterone + acetate + A + H2O
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?
17alpha-hydroxypregnenolone + AH2 + O2
dehydroepiandrosterone + acetate + A + H2O
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?
17alpha-hydroxypregnenolone + AH2 + O2
dehydroepiandrosterone + acetate + A + H2O
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?
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
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17,20-lyase activity
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?
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
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17,20-lyase activity
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?
7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2
7-dehydro-dehydroepiandrosterone + acetate + A + H2O
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?
7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2
7-dehydro-dehydroepiandrosterone + acetate + A + H2O
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?
7-dehydro-pregnenolone + AH2 + O2
7-dehydro-17alpha-hydroxypregnenolone + A + H2O
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?
7-dehydro-pregnenolone + AH2 + O2
7-dehydro-17alpha-hydroxypregnenolone + A + H2O
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?
7-dehydro-pregnenolone + AH2 + O2
7-dehydro-17alpha-hydroxypregnenolone + A + H2O
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?
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2
17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
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?
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2
17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + AH2 + O2
17alpha-hydroxyprogesterone + A + H2O
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?
progesterone + [reduced NADPH-hemoprotein reductase] + O2
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
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?
progesterone + [reduced NADPH-hemoprotein reductase] + O2
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
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?
additional information
?
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the bison enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview
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additional information
?
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the bovine enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview
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?
additional information
?
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the goat enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview
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?
additional information
?
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the guinea pig enzyme belongs to the DELTA4-type CYP17, which has no, or very low, 17,20-lyase activity with 17alpha-hydroxy-pregnenolone with the formation of dehydroepiandrosterone, substrate specificity, comparison of different species, overview
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?
additional information
?
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the horse enzyme belongs to the DELTA4,5-type of CYP17, which catalyses the 17alpha-hydroxylation of progesterone and pregnenolone and the 17,20-lyase reaction of 17alpha-hydroxy-progesterone and 17alpha-hydroxy-pregnenolone, substrate specificity, comparison of different species, overview
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?
additional information
?
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the cat enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview
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?
additional information
?
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acute elevation of serum insulin levels into the high physiological range selectively inhibits enzyme activity in man. This enzymatic step is involved in biosynthesis of the adrenal androgens androstenedione and dehydroepiandrosterone (DHEA)
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additional information
?
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the human enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview
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?
additional information
?
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adrenal cytochrome P450C17 enzyme is capable of transforming pregnenolone into DHEA
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additional information
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substrate specificity, comparison of different species, overview
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additional information
?
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cytochrome P-450c17 mediates both 17alpha-hydroxylase and 17,20 lyase activities in the synthesis of steroid hormones
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additional information
?
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enzyme of the biosynthetic pathway for testosterone synthesis. Impairment of the reaction occurs in autoimmunized rabbits with severe damage of testes
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additional information
?
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the sheep enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview
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?
additional information
?
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the chimp enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview
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?
additional information
?
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the baboon enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview
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?
additional information
?
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the rat enzyme belongs to the DELTA4,5-type of CYP17, which catalyses the 17alpha-hydroxylation of progesterone and pregnenolone and the 17,20-lyase reaction of 17alpha-hydroxy-progesterone and 17alpha-hydroxy-pregnenolone, substrate specificity, comparison of different species, overview
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?
additional information
?
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the pig enzyme belongs to the DELTA4,5-type of CYP17, which catalyses the 17alpha-hydroxylation of progesterone and pregnenolone and the 17,20-lyase reaction of 17alpha-hydroxy-progesterone and 17alpha-hydroxy-pregnenolone, substrate specificity, comparison of different species, overview
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?