1.14.14.32: 17alpha-hydroxyprogesterone deacetylase

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For detailed information about 17alpha-hydroxyprogesterone deacetylase, go to the full flat file.

Reaction

Synonyms

17,20 lyase, 17-20 lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/C17,20-lyase, 17alpha-hydroxylase, 17alpha-hydroxylase-C(17,20)-lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/17,20-lyase cytochrome P450, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-hydroxylase/C17,20-lyase, 17alpha-hydroxyprogesterone aldolase, 17alpha-hydroxyprogesterone aldolase/17,20-lyase, 17alpha-lyase, Adrenal 17,20-lyase, aldolase, 17alpha-hydroxyprogesterone, C-17,20 lyase, C-17/C-20 lyase, C17(20) lyase, C17,20 lyase, C17,20-lyase, CYP17, CYP17A1, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450c17, EC 4.1.2.30, P-45017alpha, P450 17A1, P45017alpha, P450c17, P450c17-I, steroid 17alphahydroxylase/17,20-lyase, Steroid C17(20) lyase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.32 17alpha-hydroxyprogesterone deacetylase

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Results	in table
19	Activating Compound
818	AA Sequence
10	Application
1	CAS Registry Number
20	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
3627	Disease/ Diagnostics
5	Expression
11	General Information
84	IC50 Value
170	Inhibitors
11	kcat/KM [mM/s]
10	Ki Value [mM]
20	KM Value [mM]
38	Localization
3	Molecular Weight [Da]
59	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
207	Organism
7	Pathway
26	PDB ID
2	pH Optimum
2	Posttranslational Modification
32	Protein Variants
3	Reaction
9	Reaction Type
67	Reference
84	Source Tissue
15	Specific Activity [micromol/min/mg]
117	Substrates and Products (Substrate)
2	Subunits
109	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
13	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.14.14.32 - 17alpha-hydroxyprogesterone deacetylase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

resonance Raman spectroscopy of ferric form reveals that binding of substrate causes variable degrees of conversion from the low spin to high spin state, with the nonhydroxylated progesterone and pregnenolone yielding almost complete high spin form, while the two hydroxylated substrates (17-hydroxyprogesterone and 17-hydroxypregnenolone) give only about a 60% conversion to high spin. The heme structure and its interactions with the active site protein residues remain constant for all four substrates

Homo sapiens

P05093

737703