Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.14.32: 17alpha-hydroxyprogesterone deacetylase

This is an abbreviated version!
For detailed information about 17alpha-hydroxyprogesterone deacetylase, go to the full flat file.

Word Map on EC 1.14.14.32

Reaction

17alpha-hydroxypregnenolone
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
3beta-hydroxyandrost-5-en-17-one
 +
acetate
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

17,20 lyase, 17-20 lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/C17,20-lyase, 17alpha-hydroxylase, 17alpha-hydroxylase-C(17,20)-lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/17,20-lyase cytochrome P450, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-hydroxylase/C17,20-lyase, 17alpha-hydroxyprogesterone aldolase, 17alpha-hydroxyprogesterone aldolase/17,20-lyase, 17alpha-lyase, Adrenal 17,20-lyase, aldolase, 17alpha-hydroxyprogesterone, C-17,20 lyase, C-17/C-20 lyase, C17(20) lyase, C17,20 lyase, C17,20-lyase, CYP17, CYP17A1, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450c17, EC 4.1.2.30, P-45017alpha, P450 17A1, P45017alpha, P450c17, P450c17-I, steroid 17alphahydroxylase/17,20-lyase, Steroid C17(20) lyase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.32 17alpha-hydroxyprogesterone deacetylase

Cloned

Cloned on EC 1.14.14.32 - 17alpha-hydroxyprogesterone deacetylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Pichia pastoris
-
full length cDNA clone encoding cytochrome P-450c17 (17alpha-hydrolase/17,20 lyase), expression in mammalian COS-1 cells
-
full length cDNA clone encoding cytochrome P450C17 expressed in COS 1 cells
-
gene CYP17A1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, expression of wild-type and mutant enzymes in COS-1 cells
gene encoding cytochrome P450 17alpha-hydrolase/C17-20-lyase (P450 17alpha)
-
recombinant expression in Escherichia coli
-
sequence comparisons and phylogenetic analysis
wild-type or mutant CYP17A1 cDNA, after addition of an N-terminal myc-tag, inserted into a pcDNA3.1 vector, transiently transfected into confluent COS-1 cells
-