1.14.14.3: bacterial luciferase

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For detailed information about bacterial luciferase, go to the full flat file.

Word Map on EC 1.14.14.3

1.14.14.3

metastasis

transwell

bioluminescence

chromatin

lncrnas

sponge

tumorigenesis

endothelial

3\'utr

transactivation

firefly

3'-untranslated

necrosis

agonist

tnf

prostate

estrogen

sp1

luminescence

nude

nf-kappab

5'-flanking

epithelial-mesenchymal

co-transfection

cyclin

glioma

nsclc

emsas

ovarian

carcinogenesis

mapks

pull-down

hypoxia-inducible

osteoblast

erk

non-small

bcl-2

adenovirus

osteosarcoma

chemoresistance

stat3

pten

c-jun

tunel

e-cadherin

cardiomyocytes

transcription-quantitative

runx2

osteogenic

homeobox

biotechnology

agriculture

diagnostics

medicine

molecular biology

analysis

Reaction

Synonyms

4a-hydroperoxy-4a,5-dihydroFMN intermediate luciferase, aldehyde monooxygenase, alkanal monooxygenase (FMN), bacterial luciferase, COB, Gluc luciferase, HFOOH, luciferase, Lux, LuxA, LuxAB, LuxB, LuxCDABE, LuxF, Vibrio fischeri luciferase, Vibrio harveyi luciferase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.3 bacterial luciferase

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Results	in table
13	Activating Compound
1851	AA Sequence
35	Application
1	CAS Registry Number
55	Cloned(Commentary)
46	Cofactor
6	Crystallization (Commentary)
9	General Information
31	General Stability
13	IC50 Value
93	Inhibitors
106	KM Value [mM]
8	Localization
2	Metals/Ions
21	Molecular Weight [Da]
102	Natural Substrates/ Products (Substrates)
164	Organism
1	Oxidation Stability
1	Pathway
18	PDB ID
18	pH Optimum
3	pH Stability
93	Protein Variants
24	Purification (Commentary)
6	Reaction
3	Reaction Type
163	Reference
10	Renatured (Commentary)
5	Specific Activity [micromol/min/mg]
6	Storage Stability
364	Substrates and Products (Substrate)
20	Subunits
102	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
18	Temperature Stability [°C]
10	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.14.3 - bacterial luciferase

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long-chain-aldehyde,FMNH2:oxygen oxidoreductase (1-hydroxylating, luminescing)

The reaction sequence starts with the incorporation of a molecule of oxygen into reduced FMN bound to the enzyme, forming luciferase peroxyflavin. The peroxyflavin interacts with an aliphatic long-chain aldehyde, producing a highly fluorescent species believed to be luciferase hydroxyflavin. The enzyme is highly specific for reduced FMN and for long-chain aliphatic aldehydes with eight carbons or more. The highest efficiency is achieved with tetradecanal. cf. EC 1.13.12.18, dinoflagellate luciferase.