1.14.14.3: bacterial luciferase
This is an abbreviated version!
For detailed information about bacterial luciferase, go to the full flat file.
Word Map on EC 1.14.14.3
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1.14.14.3
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metastasis
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transwell
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bioluminescence
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chromatin
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lncrnas
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sponge
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tumorigenesis
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endothelial
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3\'utr
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transactivation
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firefly
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3'-untranslated
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necrosis
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agonist
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tnf
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prostate
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estrogen
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sp1
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luminescence
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nude
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nf-kappab
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5'-flanking
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epithelial-mesenchymal
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co-transfection
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cyclin
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glioma
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nsclc
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emsas
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ovarian
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carcinogenesis
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mapks
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pull-down
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hypoxia-inducible
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osteoblast
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erk
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non-small
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bcl-2
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adenovirus
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osteosarcoma
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chemoresistance
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stat3
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pten
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c-jun
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tunel
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e-cadherin
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cardiomyocytes
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transcription-quantitative
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runx2
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osteogenic
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homeobox
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biotechnology
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agriculture
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diagnostics
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medicine
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molecular biology
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analysis
- 1.14.14.3
- metastasis
-
transwell
-
bioluminescence
- chromatin
- lncrnas
- sponge
- tumorigenesis
- endothelial
-
3\'utr
-
transactivation
- firefly
-
3'-untranslated
- necrosis
- agonist
- tnf
- prostate
- estrogen
- sp1
-
luminescence
-
nude
- nf-kappab
-
5'-flanking
-
epithelial-mesenchymal
-
co-transfection
- cyclin
- glioma
-
nsclc
-
emsas
- ovarian
- carcinogenesis
- mapks
-
pull-down
-
hypoxia-inducible
- osteoblast
- erk
-
non-small
- bcl-2
- adenovirus
- osteosarcoma
-
chemoresistance
- stat3
- pten
- c-jun
-
tunel
- e-cadherin
- cardiomyocytes
-
transcription-quantitative
- runx2
-
osteogenic
-
homeobox
- biotechnology
- agriculture
- diagnostics
- medicine
- molecular biology
- analysis
Reaction
Synonyms
4a-hydroperoxy-4a,5-dihydroFMN intermediate luciferase, aldehyde monooxygenase, alkanal monooxygenase (FMN), bacterial luciferase, COB, Gluc luciferase, HFOOH, luciferase, Lux, LuxA, LuxAB, LuxB, LuxCDABE, LuxF, Vibrio fischeri luciferase, Vibrio harveyi luciferase
ECTree
1.14.14.3 bacterial luciferaseAdvanced search results
results (
results (Subunits
Subunits on EC 1.14.14.3 - bacterial luciferase
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SUBUNIT 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dimer
heterodimer
homodimer
additional information
dimer
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alphabeta heterodimer containing a single active site at a cleft in the alpha subunit
heterodimer
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alpha-subunit, encoded by the luxA gene, and beta-subunit, encoded by the luxB gene
heterodimer
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alpha-subunit, encoded by the luxA gene, and beta-subunit, encoded by the luxB gene
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additional information
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analysis of subunit interface structure and role in the conformational stability of the heterodimeric enzyme, the beta-sunbunit can self-associate to form a stable but inactive homodimer, unfolding in a four-state mechanism
additional information
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functional roles of conserved residues in the protease-labile, unstructured loop of the alpha-subunit, formed by residues 257-291, the loop undergoed conformational changes during catalysis, overview
additional information
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structure-function relationship, roles of Cys106, Ala75, Ala74, and the isoalloxazine ring of FMN
additional information
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luciferase is composed of two homologous subunits designated alpha and beta, both of which assume the TIM barrel fold. Although the beta-subunit is required for activity, the catalytic site resides exclusively on the alpha-subunit. The most substantial compositional difference between subunits corresponds to a highly conserved stretch of residues between positions 260 and 290 unique to the alpha chains of luminous bacteria. In the luciferase/FMN complex, the asymmetric unit contains two beta/alpha-heterodimers
