1.14.14.26: 24-hydroxycholesterol 7alpha-hydroxylase

This is an abbreviated version!
For detailed information about 24-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.26

Reaction

(24S)-cholest-5-ene-3beta,24-diol
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
(24S)-cholest-5-ene-3beta,7alpha,24-triol
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

24-hydroxycholesterol 7alpha-monooxygenase, Cyp39a1, CYP39A1 oxysterol 7alpha-hydroxylase, oxysterol 7alpha-hydroxylase CYP39A1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.26 24-hydroxycholesterol 7alpha-hydroxylase

Systematic Name

Systematic Name on EC 1.14.14.26 - 24-hydroxycholesterol 7alpha-hydroxylase

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SYSTEMATIC NAME
IUBMB Comments
(24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
A P-450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24S)-cholest-5-ene-3beta,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.