1.14.14.26: 24-hydroxycholesterol 7alpha-hydroxylase

This is an abbreviated version!
For detailed information about 24-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.26

Reaction

(24S)-cholest-5-ene-3beta,24-diol
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
(24S)-cholest-5-ene-3beta,7alpha,24-triol
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

24-hydroxycholesterol 7alpha-monooxygenase, Cyp39a1, CYP39A1 oxysterol 7alpha-hydroxylase, oxysterol 7alpha-hydroxylase CYP39A1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.26 24-hydroxycholesterol 7alpha-hydroxylase

Reference

Reference on EC 1.14.14.26 - 24-hydroxycholesterol 7alpha-hydroxylase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Li-Hawkins, J.; Lund, E.G.; Bronson, A.D.; Russell, D.W.
Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol
J. Biol. Chem.
275
16543-16549
2000
Homo sapiens, Mus musculus (Q9JKJ9), Mus musculus
Manually annotated by BRENDA team
Ikeda, H.; Ueda, M.; Ikeda, M.; Kobayashi, H.; Honda, Y.
Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye
Lab. Invest.
83
349-355
2003
Bos taurus
Manually annotated by BRENDA team