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1.14.14.23: cholesterol 7alpha-monooxygenase

This is an abbreviated version!
For detailed information about cholesterol 7alpha-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.23

Reaction

cholesterol
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
7alpha-hydroxycholesterol
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

7alpha-hydroxylase, bile acid-synthetic enzyme, C7alphaOH, cholesterol 7 alpha-hydroxylase, cholesterol 7-alpha hydroxylase, Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase, cholesterol 7a-hydroxylase, cholesterol 7alpha hydroxylase, cholesterol 7alpha-hydroxylase, cholesterol-NADPH oxidoreductase, 7alpha-hydroxylating, CYP125A4, CYP7A, CYP7A1, Cyp7alpha1, CYPVII, cytochrome P450 125A4, EC 1.14.13.17, hepatic cholesterol 7alpha-hydroxylase, More, oxygenase, cholesterol 7alpha-mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.23 cholesterol 7alpha-monooxygenase

Cloned

Cloned on EC 1.14.14.23 - cholesterol 7alpha-monooxygenase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Cyp7a1 expression pattern in wild-type and Cyp8b1 null mice livers, overview
-
Cyp7a1-tg mice overexpressing rat Cyp7a1 complementary DNA under an ApoE3 hepatic control region
expressed in Mus musculus liver
-
expression in Escherichia coli
expression of His6-tagged enzyme in Escherichia coli strain BL21(DE3), stable expression of CYP7A cDNA using the cytomegalovirus promoter and the bovine growth hormone polyadenylation signal in Hep-G2 cells
gene CYP7A1, DNA sequence determination and analysis, phylogenetic tree, expression analysis and regulation, overview
gene Cyp7a1, enzyme expression analysis
gene CYP7A1, genetic structure, the gene contains six exons and five introns and is located on chromosome 8 at 8q11-q12, CYP7A1 mRNA levels are regulated through the farnesoid X receptor and the liver X receptor by many stimuli including cholesterol, bile acids, cytokines, steroid hormones, and thyroid hormone
gene CYP7A1, genotyping, overview. Expression of promoter constructs in HepG2 cells
-
gene CYP7A1, transient expression in Hep-G2 cells
gene CYP7AI, genotyping, overexpression of genetic variants in Hep-G2 cells
-
mutant Cyp7A1 promoter fragment cloned luciferase construct is generated using wild-type CYP7A1 promoter cloned luciferase, the gene contains a HSF-1 binding site in the CYP7A1 promoter region, oligonucleotides corresponding to -922 to -901 bases
native and mutated genes expressed in COS-1 cells
-
recombinant enzyme expressed in transgenic mice
-