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1.14.14.22: dibenzothiophene sulfone monooxygenase

This is an abbreviated version!
For detailed information about dibenzothiophene sulfone monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.22

Reaction

dibenzothiophene-5,5-dioxide
+
FMNH2
 +
NADH
 +
O2
=
2'-hydroxybiphenyl-2-sulfinate
 +
H2O
 +
FMN
 +
NAD+
 +
H+

Synonyms

BdsA, DBT sulfone monooxygenase, DBTO2-MO, DBTO2-monooxygenase, dibenzothiophene sulfone monooxygenase, dszA, TdsA

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.22 dibenzothiophene sulfone monooxygenase

Engineering

Engineering on EC 1.14.14.22 - dibenzothiophene sulfone monooxygenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L346A
-
site-directed mutagenesis, the mutant shows an unaltered substrate specificity compared to the wild-type enzyme
Q345A
-
site-directed mutagenesis, the mutant strain can degrade octyl sulfide on which the wild-type strain cannot grow. the DszA change at residue 345 results in an altered C-S bond cleavage pattern of 3-methyl DBT sulfone
T344A
-
site-directed mutagenesis, the mutant shows an unaltered substrate specificity compared to the wild-type enzyme
T344A/Q345A
-
site-directed mutagenesis, the mutant strain can degrade octyl sulfide on which the wild-type strain cannot grow. the DszA change at residue 345 results in an altered C-S bond cleavage pattern of 3-methyl DBT sulfone
L346A
Rhodococcus erythropolis IGTS8 / ATCC 53968
-
site-directed mutagenesis, the mutant shows an unaltered substrate specificity compared to the wild-type enzyme
-
Q345A
Rhodococcus erythropolis IGTS8 / ATCC 53968
-
site-directed mutagenesis, the mutant strain can degrade octyl sulfide on which the wild-type strain cannot grow. the DszA change at residue 345 results in an altered C-S bond cleavage pattern of 3-methyl DBT sulfone
-
T344A
Rhodococcus erythropolis IGTS8 / ATCC 53968
-
site-directed mutagenesis, the mutant shows an unaltered substrate specificity compared to the wild-type enzyme
-
T344A/Q345A
Rhodococcus erythropolis IGTS8 / ATCC 53968
-
site-directed mutagenesis, the mutant strain can degrade octyl sulfide on which the wild-type strain cannot grow. the DszA change at residue 345 results in an altered C-S bond cleavage pattern of 3-methyl DBT sulfone
-
additional information