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1.14.14.20: phenol 2-monooxygenase (FADH2)

This is an abbreviated version!
For detailed information about phenol 2-monooxygenase (FADH2), go to the full flat file.

Word Map on EC 1.14.14.20

Reaction

phenol
+
FADH2
+
O2
=
catechol
+
FAD
+
H2O

Synonyms

FAD reductase, flavin reductase PheA2, PheA, PheA1, PheA2, phenol hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.20 phenol 2-monooxygenase (FADH2)

Systematic Name

Systematic Name on EC 1.14.14.20 - phenol 2-monooxygenase (FADH2)

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SYSTEMATIC NAME
IUBMB Comments
phenol,FADH2:oxygen oxidoreductase (2-hydroxylating)
The enzyme catalyses the ortho-hydroxylation of simple phenols into the corresponding catechols. It accepts 4-methylphenol, 4-chlorophenol, and 4-fluorophenol [1] as well as 4-nitrophenol, 3-nitrophenol, and resorcinol [3]. The enzyme is part of a two-component system that also includes an NADH-dependent flavin reductase. It is strictly dependent on FADH2 and does not accept FMNH2 [1,3]. cf. EC 1.14.13.7, phenol 2-monooxygenase (NADPH).