1.14.14.19: steroid 17alpha-monooxygenase

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For detailed information about steroid 17alpha-monooxygenase, go to the full flat file.

Reaction

Synonyms

17 alpha-hydroxylase/C17,20-lyase, 17,20-lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/17,20-lyase, 17-hydroxylase/C17,20-lyase, 17alpha
hydroxylase, 17alpha-hydroxylase, 17alpha-hydroxylase 17,20 lyase, 17alpha-hydroxylase-17,20-lyase, 17alpha-hydroxylase-C17,20 lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-OHase, 17OHD, CYP 17, CYP17, CYP17A1, CYPXVII, cytochrome P-450 (P45017alpha,lyase), cytochrome P-45017alpha, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17A2, cytochrome P450 17alpha-hydroxylase, cytochrome P450 17alpha-hydroxylase-17,20-lyase, cytochrome P450 17alpha-hydroxylase/17,20 lyase, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450 17alpha-hydroxylase/C17,20-lyase, cytochrome P450 17alpha-hydroxylase/c17-20 lyase, cytochrome P45017alpha, cytochrome P450c17, cytochrome P450c17alpha, cytochromeP450 17alpha-hydroxylase/C17-20 lyase, EC 1.14.1.7, EC 1.14.99.9, EC 1.99.1.9, P450 17, P450 17A1, P450(17alpha), P450-17alpha, P450-C17, P45017alpha, P450c17, P450c17-I, Steroid 17-alpha-hydroxylase/17,20 lyase, steroid 17alpha-hydroxylase, steroidogenic cytochrome P450 17A1

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.19 steroid 17alpha-monooxygenase

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Results	in table
12	Activating Compound
840	AA Sequence
12	Application
1	CAS Registry Number
45	Cloned(Commentary)
42	Cofactor
4	Crystallization (Commentary)
698	Disease/ Diagnostics
5	Expression
91	General Information
246	IC50 Value
500	Inhibitors
10	kcat/KM [mM/s]
55	Ki Value [mM]
47	KM Value [mM]
48	Localization
11	Metals/Ions
8	Molecular Weight [Da]
140	Natural Substrates/ Products (Substrates)
294	Organism
8	Pathway
34	PDB ID
26	pH Optimum
5	Posttranslational Modification
52	Protein Variants
20	Purification (Commentary)
2	Reaction
10	Reaction Type
124	Reference
149	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
181	Substrates and Products (Substrate)
6	Subunits
156	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
1	Temperature Range [°C]
18	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.14.14.19 - steroid 17alpha-monooxygenase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

CYP21

Homo sapiens

P05093

direct molecular interactions, with electrostatic interactions playing a crucial role, between steroidogenic enzymes CYP17 and CYP21, EC 1.14.99.10, that are localized in endoplasmic reticulum membranes of adrenal cortex and involved in biosynthesis of corticosteroid hormones. The interaction in vitro reduces the catalytic activities of both enzymes at high ionic strength, i.e. 300 mM NaCl, while it increases activity at low ionic strength, i.e. 100 mM NaCl, overview

726923

-

cytochrome b5

6 entries

-

phosphatidylcholine

Sus scrofa

-

incorporation of P450 into liposomal membranes composed of phosphatidylcholine increases activity

390134

additional information

4 entries

-

cytochrome b5

Cavia porcellus

-

above pH 6.3-6.5 stimulates 17alpha-hydrolase and c17,20-lyase activity

390139

-

cytochrome b5

Homo sapiens

-

-

390122

-

cytochrome b5

Homo sapiens

P05093

acts as allosteric facilitator but not as electron donor, increases 17,20-lyase activity

390120

-

cytochrome b5

Homo sapiens

-

specific stimulation of 17,20-lyase activity of enzyme, up to 10fold increase in lyase activity, while 17alpha-hydroxylase activity is little affected

672187

-

cytochrome b5

Homo sapiens

-

expression of cytochrome b5 in the zona reticularis, at the onset of adrenarche, increases along with the acyl-carbon bond cleavage activity of CYP17, cytochrome plays a regulatory role for CYP17 activity

716053

-

cytochrome b5

Homo sapiens

P05093

recombinant human microsomal wild-type protein and mutants E48Q, E49Q, and V50S, enzyme interaction analysis by NMR, overview. Substrate-modulated interactions of cytochrome P450 17A1 and cytochrome b5, by reversible binding, involving enzyme anionic residues Glu48 or Glu49 and corresponding cationic CYP17A1 residues Arg347, Arg358, and Arg449. The CYP17A1/b5 interaction is stronger when the hydroxylase substrate pregnenolone is present in the CYP17A1 active site than when the lyase substrate 17alpha-hydroxypregnenolone is in the active site

727947

-

additional information

Bos taurus

-

cytochrome B5 does not affect the 17alpha-hydroxylase activity

686364

-

additional information

Cavia porcellus

-

cytochrome B5 does not affect the 17alpha-hydroxylase activity

686364

-

additional information

Homo sapiens

-

not activating: antiepileptic drugs valproic acid, carbamazepine, topiramate, lamotrigine

673400

-

additional information

Sus scrofa

-

cytochrome B5 does not affect the 17alpha-hydroxylase activity

686364

-