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1.14.14.18: heme oxygenase (biliverdin-producing)

This is an abbreviated version!
For detailed information about heme oxygenase (biliverdin-producing), go to the full flat file.

Word Map on EC 1.14.14.18

Reaction

protoheme
+ 3 [reduced NADPH-hemoprotein reductase] + 3 O2 =
Biliverdin
+
Fe2+
+
CO
+ 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O

Synonyms

biliverdin-producing heme oxygenase, ChuS, ChuZ, EC 1.14.99.3, haem oxygenase, heme oxygenase, heme oxygenase 1, heme oxygenase 2, heme oxygenase-1, heme oxygenase-2, HemO, Hmox1, Hmox1a, Hmox1b, Hmox2, Hmox2a, Hmox2b, HmuO, Hmx1, HO, HO-1, HO-2, Ho1, Ho2, Ho3, HO4, HSP32, HugZ, HY1, inducible heme oxygenase-1, More, MsHO1, ORP33 proteins, oxygenase, heme (decyclizing), pbsA1, PigA, proteins, specific or class, ORP33 (oxygen-regulated protein 33,000-mol.-wt.), Syn HO-1, Syn HO-2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.18 heme oxygenase (biliverdin-producing)

Molecular Weight

Molecular Weight on EC 1.14.14.18 - heme oxygenase (biliverdin-producing)

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
150000
-
gel filtration
180000
-
gel filtration
200000
21600
-
calculated from amino acid sequence
23450
-
MALDI-TOF
24000
-
x * 24000, SDS-PAGE, deduced from amino acid sequence
25000
26000
-
SDS-PAGE
27000
-
1 * 27000, HY1, SDS-PAGE. HY1, HO3 and HO4, gel filtration
28000
30000
-
x * 30000, liver heme oxygenase-1, SDS-PAGE
30500
-
x * 30500, SDS-PAGE
30700
-
x * 30700, liver heme oxygenase-1, SDS-PAGE
31000
-
x * 31000, SDS-PAGE
32000
33000
36000
36500
x * 36500, isozyme HO-2
42000
-
x * 42000, heme oxygenase-2, SDS-PAGE
68000
-
x * 68000, possibly a trimer, SDS-PAGE
additional information
-
heme oxygenase consists of 3 components: a 22000 Da ferredoxin-like Fe/S cluster protein that can be replaced by ferredoxin, a 38000 Da protein that is inactivated by diethyldicarbonate, inactivation is blocked by heme, a 37000 Da protein with ferredoxin-linked cytochrome c reductase activity