Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.14.16: steroid 21-monooxygenase

This is an abbreviated version!
For detailed information about steroid 21-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.16

Reaction

a C21 steroid
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
a 21-hydroxy-C21-steroid
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

17alpha-hydroxyprogesterone 21-hydrolase, 21-hydroxylase, 21-hydroxylase cytochrome P-450, 21OH, C3B21RA protein, CYP21, CYP21A2, CYP2D, Cytochrome P-450 specific for steroid C-21 hydroxylation, cytochrome P-450-linked mixed function oxidase system, cytochrome P-450C-21, cytochrome p450 21A2, cytochrome P450 steroid 21-hydroxylase, cytochrome P450c21, EC 1.14.1.8, EC 1.14.99.10, EC 1.99.1.11, P-450(C21), P450 oxidoreductase-21-hydroxylase, P450-C21, P450-C21B, P450c21, Progesterone 21-hydroxylase, Steroid 21-hydroxylase, steroid 21-hydroxylase system, steroid 21-hydroxylation system, steroid cytochrome P450 21-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.16 steroid 21-monooxygenase

Specific Activity

Specific Activity on EC 1.14.14.16 - steroid 21-monooxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00027
-
37°C, mutant P482S, substrate 17-hydroxy-progesterone
0.00038
-
37°C, mutant P482S, substrate progesterone
0.00117
-
37°C, wild-type, substrate progesterone
0.00122
-
37°C, wild-type, substrate 17-hydroxy-progesterone
0.00129
-
37°C, mutant A15T, substrate 17-hydroxy-progesterone
0.00148
-
37°C, mutant A15T, substrate progesterone
0.003
-
21-hydroxylation of progesterone at 26°C
0.0038
-
21-hydroxylation of 17alpha-hydroxyprogesterone at 26°C
0.0052
-
N-demethylation of (+)-benzphetamine
0.0077
-
21-hydroxylation of progesterone
0.0144
-
21-hydroxylation of progesterone
0.0195
-
cytochrome P-450-linked mixed function oxidase system from adrenal gland, 21-hydroxylation of 17alpha-hydroxyprogesterone
0.0452
-
21-hydroxylation of 17alpha-hydroxyprogesterone