1.14.14.102: N-methylcoclaurine 3'-monooxygenase
This is an abbreviated version!
For detailed information about N-methylcoclaurine 3'-monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.102
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1.14.14.102
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poppy
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3\'-hydroxylase
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berberine
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benzylisoquinoline
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s-n-methylcoclaurine
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opium
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codeinone
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sanguinarine
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somniferum
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papaver
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s-reticuline
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elicitors
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6-o-methyltransferase
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narcotic
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norcoclaurine
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n-methyltransferase
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jasmonate
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4\'omt
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p-450-dependent
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penultimate
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benzophenanthridine
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eschscholzia
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californica
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latex
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laticifers
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coptis
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thebaine
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papaverine
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3'-hydroxylation
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branch-point
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morphinan
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7-o-acetyltransferase
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analgesics
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sieve
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jasmonate-induced
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biotechnology
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medicine
- 1.14.14.102
- poppy
-
3\'-hydroxylase
- berberine
-
benzylisoquinoline
-
s-n-methylcoclaurine
-
opium
- codeinone
- sanguinarine
- somniferum
- papaver
-
s-reticuline
- elicitors
-
6-o-methyltransferase
-
narcotic
- norcoclaurine
- n-methyltransferase
- jasmonate
-
4\'omt
-
p-450-dependent
-
penultimate
-
benzophenanthridine
- eschscholzia
- californica
- latex
-
laticifers
-
coptis
- thebaine
- papaverine
-
3'-hydroxylation
-
branch-point
-
morphinan
-
7-o-acetyltransferase
-
analgesics
-
sieve
-
jasmonate-induced
- biotechnology
- medicine
Reaction
Synonyms
(S)-methylcoclaurine-3'-hydroxylase, (S)-N-methylcoclaurine 3'-hydroxylase, (S)-N-methylcoclaurine-3'-hydroxylase, (S)-N-methylcoclaurine-3-hydroxylase, CYP80B, CYP80B1, CYP80B3, Cytochrome P450 80B1, Cytochrome P450 80B2, EC 1.14.13.71, LOC104585940, N-methylcoclaurine 3'-hydroxylase, NMCH
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General Information
General Information on EC 1.14.14.102 - N-methylcoclaurine 3'-monooxygenase
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malfunction
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enzyme silencing is associated with a 22% reduction in total alkaloid accumulation, with a notable decrease in the levels of thebaine and codeine compared with controls. In contrast, absolute levels of morphine and papaverine are not affected
metabolism
physiological function
the expression of isozyme 1 is low in the two cultivars, so it may have little effect on alkaloid contents. The expression of CYP80B, NNU08355, has a positive effect on aporphine alkaloids content in lotus, but exhibits phenotypic lag, which might be because of NMCH which acts early in the benzylisoquinoline alkaloid biosynthetic pathway
metabolism
the enzyme is involved in the common pathway of benzylisoquinoline alkaloid biosynthesis and the aporphine alkaloid bisynthesis pathway in lotus, overview. A series of enzymes, norcoclaurine 6-O-methyltransferase (6OMT), coclaurineN-methyltransferase (CNMT), (S)-N-methylcoclaurine-3-hydroxylase (NMCH), and 3-hydroxy-N-methylcoclaurine 4'-O-methyltransferase(4'OMT), exhibit catalytic activity to yield the central branchpoint intermediate (S)-reticuline