1.14.14.102: N-methylcoclaurine 3'-monooxygenase

This is an abbreviated version!
For detailed information about N-methylcoclaurine 3'-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.102

Reaction

(S)-N-methylcoclaurine
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
(S)-3'-hydroxy-N-methylcoclaurine
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

N-methylcoclaurine 3'-hydroxylase, Cytochrome P450 80B1, Cytochrome P450 80B2, CYP80B1, (S)-N-methylcoclaurine 3'-hydroxylase, (S)-methylcoclaurine-3'-hydroxylase, CYP80B3, (S)-N-methylcoclaurine-3'-hydroxylase, NMCH, (S)-N-methylcoclaurine-3-hydroxylase, LOC104585940, CYP80B

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.102 N-methylcoclaurine 3'-monooxygenase

General Information

General Information on EC 1.14.14.102 - N-methylcoclaurine 3'-monooxygenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the expression of isozyme 1 is low in the two cultivars, so it may have little effect on alkaloid contents. The expression of CYP80B, NNU08355, has a positive effect on aporphine alkaloids content in lotus, but exhibits phenotypic lag, which might be because of NMCH which acts early in the benzylisoquinoline alkaloid biosynthetic pathway
malfunction
-
enzyme silencing is associated with a 22% reduction in total alkaloid accumulation, with a notable decrease in the levels of thebaine and codeine compared with controls. In contrast, absolute levels of morphine and papaverine are not affected
metabolism