1.14.13.81: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase

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For detailed information about magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase, go to the full flat file.

Reaction

Synonyms

AcsF, AcsF protein, aerobic Mg-protoporphyrin IX monomethyl ester cyclase, ATZIP protein, BChE, BNZIP protein, CHL27, CHL27 protein, CRD1, Crd1 protein, CSZIP protein, Cth1 protein, CycI, cyclase, magnesium protoporphyrin IX monomethyl ester, LCAA, LOC_Os01g17170, magnesium protoporphyrin IX monomethyl ester cyclase, magnesium protoporphyrin monomethylester oxidative cyclase, magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase, magnesium-protoporphyrin IX monomethyl ester cyclase, magnesium-protoporphyrin-IX monomethyl ester cyclase, magnesium-protoporphyrin-IX monomethyl ester oxidative cyclase, Mg protoporphyrin monomethylester cyclase, Mg-protoporphyrin IX methyl ester cyclase, Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase, Mg-protoporphyrin IX monomethyl ester cyclase, Mg-protoporphyrin IX monomethylester cyclase system, Mg-protoporphyrin monomethylester cyclase, MgPME cyclase, MgPME oxidative cyclase, MPE cyclase, MPE cyclase system, MPE-cyclase, MPEC, MPEC gene product, MPME cyclase, NTZIP protein, O2-dependent Mg-protoporphyrin monomethyl ester cyclase, OsCRD1, OSZIP protein, oxygen-dependent Mg-protoporphyrin IX monomethylester cyclase system, oxygen-independent Mg-protoporphyrin IX monomethylester cyclase system, PeMPEC, PNZIP protein, RDZIP protein, rice copper response defect 1, SBZIP protein, Sll1214, SOZIP protein, TAZIP protein, TRZIP protein, XanL, Xantha-l, YSL1

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.81 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase

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Results	in table
13	Activating Compound
3171	AA Sequence
1	Application
1	CAS Registry Number
14	Cloned(Commentary)
33	Cofactor
7	Expression
109	General Information
26	Inhibitors
2	kcat/KM [mM/s]
3	KM Value [mM]
34	Localization
12	Metals/Ions
6	Molecular Weight [Da]
107	Natural Substrates/ Products (Substrates)
114	Organism
5	Pathway
3	pH Optimum
1	pI Value
14	Protein Variants
5	Purification (Commentary)
6	Reaction
4	Reaction Type
107	Reference
2	Renatured (Commentary)
43	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
119	Substrates and Products (Substrate)
21	Subunits
258	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.14.13.81 - magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

ascorbate

2 entries

ATP

Cucumis sativus

-

requirement for reconstituted system

636333

catalase

2 entries

-

isoascorbate

2 entries

S-adenosyl-L-methionine

2 entries

XanL

Hordeum vulgare

-

required by the enzyme, found associated with the membrane and protein Ycf54

744871

-

Ycf54

2 entries

-

Ycf54 protein

Synechocystis sp. PCC 6803

P72584

the Ycf54 protein forms a complex with the component of the oxidative cyclase, Sll1214 (CycI, gene slr1780). Partial inactivation of the ycf54 gene leads to Chl deficiency in cyanobacteria and plants, and the complete deletion of the ycf54 gene in the cyanobacterium Synechocystis 6803 results accumulation of huge concentrations of the cyclase substrate MgPME together with 3-formyl MgPME, in the DELTAycf54 strain. The Ycf54 protein is important, but not essential, for activity of the oxidative cyclase

744998

-

ascorbate

Chlamydomonas reinhardtii

-

prevents degradation of tetrapyrroles by reactive oxygen species

636329

ascorbate

Synechocystis sp.

-

prevents degradation of tetrapyrroles by reactive oxygen species

636329

catalase

Chlamydomonas reinhardtii

-

prevents degradation of tetrapyrroles by reactive oxygen species

636329

-

catalase

Synechocystis sp.

-

prevents degradation of tetrapyrroles by reactive oxygen species

636329

-

isoascorbate

Chlamydomonas reinhardtii

-

prevents degradation of tetrapyrroles by reactive oxygen species

636329

isoascorbate

Synechocystis sp.

-

prevents degradation of tetrapyrroles by reactive oxygen species

636329

S-adenosyl-L-methionine

Cucumis sativus

-

-

636332

S-adenosyl-L-methionine

Cucumis sativus

-

1 mM, absolute requirement when magnesium-protoporphyrin IX is used as substrate

636333

Ycf54

Hordeum vulgare

-

identified based upon strong association of Ycf54 with XanL. Active Ycf54 is membrane localized. The conserved chloroplast polypeptide Ycf54 is involved in the MPEC-enzyme catalyzed reaction. Sequencing, recombinant expression as His-tagged protein, and purification, UniProt ID F2D891

744871

-

Ycf54

Synechocystis sp.

-

essential for cyclase activity and/or stability forming a complex with other oxidative cyclase components Sll1214 and Sll1874

727915

-